Calcium plus vitamin D supplementation and the risk of breast cancer
Chlebowski RT, Johnson KC, Kooperberg C, Pettinger M, Wactawski-Wende J, Rohan T, Rossouw J, Lane D, O'Sullivan MJ, Yasmeen S, Hiatt RA, Shikany JM, Vitolins M, Khandekar J, Hubbell FA, Women's Health Initiative Investigators
Journal of the National Cancer Institute · 293 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2008-11-12 · J Natl Cancer Inst · vol. 100 · número 22 · págs. 1581–1591
- Editorial
- Oxford University Press
- Citado
- 427 citas · más que el 100% de estudios similares · 27.8× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 45 trabajos
- Acceso
- Acceso abierto (copia en repositorio)
- Áreas de investigación
- Vitamin D Research Studies · Nutritional Studies and Diet · Cancer Risks and Factors
- Palabras clave
- calcium supplementation, vitamin D supplementation, breast cancer risk, 25-hydroxyvitamin D, postmenopausal women, Women's Health Initiative, vitamin D intake, body mass index, physical activity, hip fracture
- MeSH
- humans, carcinoma, ductal, breast, breast neoplasms, calcium compounds, vitamin d, mammography, body mass index, drug administration schedule, incidence, proportional hazards models, odds ratio, risk assessment, risk factors, case-control studies, double-blind method, postmenopause, patient selection, dietary supplements, aged, middle aged, united states, female, kaplan-meier estimate
16 autores
- Rowan T. Chlebowski🇺🇸University of California, Los Angeles; The Lundquist Institute; Harbor–UCLA Medical Center
- Karen Johnson🇺🇸University of Tennessee Health Science Center
- Charles L Kooperberg🇺🇸Fred Hutch Cancer Center
- Mary B. Pettinger🇺🇸Fred Hutch Cancer Center
- Jean Wactawski‐Wende🇺🇸University at Buffalo, State University of New York
- Tom E. Rohan🇺🇸Yeshiva University
- Jacques E. Rossouw🇺🇸National Institutes of Health
- Dorothy S. Lane🇺🇸Stony Brook University
- Mary Jo O’Sullivan🇺🇸University of Miami
- Shagufta Yasmeen🇺🇸University of California, Davis
- Robert A. Hiatt🇺🇸University of California, San Francisco
- James M. Shikany🇺🇸University of Alabama at Birmingham
- Mara Z. Vitolins🇺🇸Wake Forest University
- Janu Khandekar🇺🇸Northwestern University
- F. Allan Hubbell🇺🇸University of California, Irvine
- for the Women's Health Initiative Investigators
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Although some observational studies have associated higher calcium intake and especially higher vitamin D intake and 25-hydroxyvitamin D levels with lower breast cancer risk, no randomized trial has evaluated these relationships.
Methods
Postmenopausal women (N = 36 282) who were enrolled in a Women's Health Initiative clinical trial were randomly assigned to 1000 mg of elemental calcium with 400 IU of vitamin D(3) daily or placebo for a mean of 7.0 years to determine the effects of supplement use on incidence of hip fracture. Mammograms and breast exams were serially conducted. Invasive breast cancer was a secondary outcome. Baseline serum 25-hydroxyvitamin D levels were assessed in a nested case-control study of 1067 case patients and 1067 control subjects. A Cox proportional hazards model was used to estimate the risk of breast cancer associated with random assignment to calcium with vitamin D(3). Associations between 25-hydroxyvitamin D serum levels and total vitamin D intake, body mass index (BMI), recreational physical activity, and breast cancer risks were evaluated using logistic regression models. Statistical tests were two-sided.
Results
Invasive breast cancer incidence was similar in the two groups (528 supplement vs 546 placebo; hazard ratio = 0.96; 95% confidence interval = 0.85 to 1.09). In the nested case-control study, no effect of supplement group assignment on breast cancer risk was seen. Baseline 25-hydroxyvitamin D levels were modestly correlated with total vitamin D intake (diet and supplements) (r = 0.19, P < .001) and were higher among women with lower BMI and higher recreational physical activity (both P < .001). Baseline 25-hydroxyvitamin D levels were not associated with breast cancer risk in analyses that were adjusted for BMI and physical activity (P(trend) = .20).
Conclusions
Calcium and vitamin D supplementation did not reduce invasive breast cancer incidence in postmenopausal women. In addition, 25-hydroxyvitamin D levels were not associated with subsequent breast cancer risk. These findings do not support a relationship between total vitamin D intake and 25-hydroxyvitamin D levels with breast cancer risk.
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