Fish oil reduces heart rate and oxygen consumption during exercise
Peoples GE, McLennan PL, Howe PR, Groeller H
Journal of cardiovascular pharmacology · 104 citas
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Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2008-12-01 · J Cardiovasc Pharmacol · vol. 52 · número 6 · págs. 540–547
- Editorial
- Lippincott Williams & Wilkins
- Citado
- 159 citas · más que el 97% de estudios similares · 6.7× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 60 trabajos
- Acceso
- De pago
- Áreas de investigación
- Fatty Acid Research and Health · Cardiovascular and exercise physiology · Muscle metabolism and nutrition
- Palabras clave
- fish oil supplementation, omega-3 polyunsaturated fatty acids, exercise oxygen consumption, heart rate, myocardial oxygen consumption, rate-pressure product, erythrocyte membrane fatty acid composition, submaximal exercise, peak oxygen uptake, endurance performance
- MeSH
- muscle, skeletal, myocardium, erythrocyte membrane, humans, docosahexaenoic acids, eicosapentaenoic acid, membrane lipids, fish oils, capsules, exercise, administration, oral, double-blind method, oxygen consumption, heart rate, muscle fatigue, time factors, dietary supplements, adult, male, young adult
4 autores
- Gregory E. Peoples🇦🇺 · autor de correspondenciaUniversity of Wollongong
- Peter L. McLennan🇦🇺 · autor de correspondenciaUniversity of Wollongong
- Peter R.C. Howe · autor de correspondencia
- Herbert Groeller
Resumen
El texto original del estudio, en el idioma en que se publicó.
Dietary omega-3 polyunsaturated fatty acids (PUFAs) are readily incorporated into heart and skeletal muscle membranes where, in the heart, animal studies show they reduce O2 consumption. To test the hypothesis that omega-3 PUFAs alter O2 efficiency in humans, the effects of fish oil (FO) supplementation on O2 consumption during exercise were evaluated. Sixteen well-trained men (cyclists), randomly assigned to receive 8 x 1 g capsules per day of olive oil (control) or FO for 8 weeks in a double-blind, parallel design, completed the study (control: n = 7, age 27.1 +/- 2.7 years; FO: n = 9, age 23.2 +/- 1.2 years). Subjects used an electronically braked cycle ergometer to complete peak O2 consumption tests (VO 2peak) and sustained submaximal exercise tests at 55% of peak workload (from the VO 2peak test) before and after supplementation. Whole-body O2 consumption and indirect measurements of myocardial O2 consumption [heart rate and rate pressure product (RPP)] were assessed. FO supplementation increased omega-3 PUFA content of erythrocyte cell membranes. There were no differences in VO 2peak (mL kg(-1) min(-1)) (control: pre 66.8 +/- 2.4, post 67.2 +/- 2.3; FO: pre 68.3 +/- 1.4, post 67.2 +/- 1.2) or peak workload after supplementation. The FO supplementation lowered heart rate (including peak heart rate) during incremental workloads to exhaustion (P < 0.05). In addition, the FO supplementation lowered steady-state submaximal exercise heart rate, whole-body O2 consumption, and RPP (P < 0.01). Time to voluntary fatigue was not altered by FO supplementation. This study indicates that FOs may act within the healthy heart and skeletal muscle to reduce both whole-body and myocardial O2 demand during exercise, without a decrement in performance.
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