Polymorphisms cyclooxygenase-2 -765G>C and interleukin-6 -174G>C are associated with serum inflammation markers in a high cardiovascular risk population and do not modify the response to a Mediterranean diet supplemented with virgin olive oil or nuts
Corella D, González JI, Bulló M, Carrasco P, Portolés O, Díez-Espino J, Covas MI, Ruíz-Gutierrez V, Gómez-Gracia E, Arós F, Fiol M, Herrera MC, Santos JM, Sáez G, Lamuela R, Lahoz C, Vinyoles E, Ros E, Estruch R
The Journal of nutrition · 37 citas
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Cómo se estudió
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- Ensayo controlado aleatorizado (indexado por PubMed)
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Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Generalitat Valenciana
- Gobierno
- Instituto de Salud Carlos III
- Subvenciones
- Instituto de Salud Carlos III (ACOMP06109); Generalitat Valenciana (ACOMP06109); Instituto de Salud Carlos III (PI41/2005)
Según 2 financiadores declarados.
Publicación
- Publicado
- 2008-12-05 · J Nutr · vol. 139 · número 1 · págs. 128–134
- Editorial
- Elsevier BV
- Citado
- 49 citas · más que el 90% de estudios similares · 2.6× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 41 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Nutrition, Genetics, and Disease · Nutritional Studies and Diet · Fatty Acid Research and Health
- Palabras clave
- cyclooxygenase-2, interleukin-6, IL-6 -174 G/C polymorphism, genetic polymorphism, inflammatory markers, C-reactive protein, ICAM-1, VCAM-1, Mediterranean diet, virgin olive oil, nuts, gene-diet interaction, cardiovascular risk, serum cytokines
- MeSH
- humans, nuts, cardiovascular diseases, inflammation, plant oils, c-reactive protein, intercellular adhesion molecule-1, vascular cell adhesion molecule-1, interleukin-6, gene expression regulation, diet, mediterranean, polymorphism, genetic, aged, middle aged, female, male, cyclooxygenase 2, biomarkers, olive oil
19 autores
- Dolores Corella🇪🇸 · autor de correspondenciaUniversitat de València; Instituto de Salud Carlos III; Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition
- José I. González🇪🇸Universitat de València; Instituto de Salud Carlos III; Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition
- Mònica Bulló🇪🇸Universitat Rovira i Virgili
- Paula Carrasco🇪🇸Universitat de València
- Olga Portolés🇪🇸Universitat de València
- Javier Díez‐Espino🇪🇸Universidad de Navarra
- María Isabel Covas🇪🇸Instituto de Salud Carlos III; Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition; Municipal Institute for Medical Research
- Valentina Ruíz-Gutiérrez🇪🇸Consejo Superior de Investigaciones Científicas; Instituto de la Grasa
- Enrique Gómez‐Gracia🇪🇸Universidad de Málaga
- Fernando Arós🇪🇸Hospital Txagorritxu
- Miquel Fiol🇪🇸Instituto de Salud Carlos III; Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition; Hospital Universitario Son Dureta
- Manuel Conde Herrera🇪🇸Hospital Universitario Virgen del Rocío
- José Manuel Santos‐Lozano🇪🇸Instituto de Salud Carlos III; Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition
- Guillermo T. Sáez🇪🇸Universitat de València
- Rosa Lamuela🇪🇸Universitat de Barcelona
- Carlos H Lahoz🇪🇸Carlos III Hospital
- Ernest Vinyoles
- Emilio Ros🇪🇸Instituto de Salud Carlos III; Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition; Consorci Institut D'Investigacions Biomediques August Pi I Sunyer; Fundació de Recerca Clínic Barcelona-Institut d’Investigacions Biomèdiques August Pi i Sunyer
- Ramón Estruch🇪🇸Instituto de Salud Carlos III; Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition; Consorci Institut D'Investigacions Biomediques August Pi I Sunyer; Fundació de Recerca Clínic Barcelona-Institut d’Investigacions Biomèdiques August Pi i Sunyer
Resumen
El texto original del estudio, en el idioma en que se publicó.
Inflammation is involved in cardiovascular diseases. Some studies have found that the Mediterranean diet (MD) can reduce serum concentrations of inflammation markers. However, none of these studies have analyzed the influence of genetic variability in such a response. Our objective was to study the effect of the -765G>C polymorphism in the cyclooxygenase-2 (COX-2) gene and the -174G>C polymorphism in the interleukin-6 (IL-6) gene on serum concentrations of IL-6, C-reactive protein, intercellular adhesion molecule 1 (ICAM-1) and vascular cell adhesion molecule-1 as well as their influence on the response to a nutritional intervention with MD. An intervention study in a high cardiovascular risk Mediterranean population (314 men and 407 women) was undertaken. Participants were randomly assigned to consume a low-fat control diet or a MD supplemented with virgin olive oil or nuts. Measures were obtained at baseline and after a 3-mo intervention period. At baseline, the COX-2 -765G>C polymorphism was associated with lower serum IL-6 (5.85 +/- 4.82 in GG vs. 4.74 +/- 4.14 ng/L in C-allele carriers; P = 0.002) and ICAM-1 (265.8 +/- 114.8 in GG vs. 243.0 +/- 107.1 microg/L in C-carriers; P = 0.018) concentrations. These differences remained significant after multivariate adjustment. The IL-6 -174G>C polymorphism was associated with higher (CC vs. G-carriers) serum ICAM-1 concentrations in both men and women and with higher serum IL-6 concentrations in men. Following the dietary intervention, no significant gene x diet interactions were found. In conclusion, although COX-2 -765G>C and IL-6 -174G>C polymorphisms were associated with inflammation, consuming a MD (either supplemented with virgin olive oil or nuts) reduced the concentration of inflammation markers regardless of these polymorphisms.
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