Estimation of the dietary requirement for vitamin D in healthy adults
Cashman KD, Hill TR, Lucey AJ, Taylor N, Seamans KM, Muldowney S, Fitzgerald AP, Flynn A, Barnes MS, Horigan G, Bonham MP, Duffy EM, Strain JJ, Wallace JM, Kiely M
The American journal of clinical nutrition · 169 citas
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- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
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- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
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- Financiación no declarada
Publicación
- Publicado
- 2008-12-01 · Am J Clin Nutr · vol. 88 · número 6 · págs. 1535–1542
- Editorial
- Elsevier BV
- Citado
- 248 citas · más que el 99% de estudios similares · 16.2× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 30 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Vitamin D Research Studies · Nutrition and Health Studies · Nutritional Studies and Diet
- Palabras clave
- vitamin D, nutrient requirements, vitamin D3 supplementation, 25-hydroxyvitamin D, vitamin D status, dose-response relationship, healthy adults, vitamin D intake
- MeSH
- humans, cholecalciferol, vitamin d, enzyme-linked immunosorbent assay, double-blind method, sunlight, ultraviolet rays, seasons, nutritional requirements, dose-response relationship, drug, reference values, nutrition policy, dietary supplements, adult, female, male, bone density conservation agents, young adult
15 autores
- Kevin D. Cashman🇮🇪 · autor de correspondenciaUniversity College Cork
- Tom R. Hill🇬🇧🇮🇪University of Ulster; University College Cork
- Alice J. Lucey🇬🇧🇮🇪University of Ulster; University College Cork
- Nicola Taylor🇬🇧🇮🇪University of Ulster; University College Cork
- Kelly M. Seamans🇬🇧🇮🇪University of Ulster; University College Cork
- Siobhan Muldowney🇬🇧🇮🇪University of Ulster; University College Cork
- Tony Fitzgerald🇬🇧🇮🇪University of Ulster; University College Cork
- Albert Flynn🇬🇧🇮🇪University of Ulster; University College Cork
- Maria S. Mulhern🇬🇧🇮🇪University of Ulster; University College Cork
- Geraldine Horigan🇬🇧🇮🇪University of Ulster; University College Cork
- Maxine P. Bonham🇬🇧🇮🇪University of Ulster; University College Cork
- Emeir M. McSorley🇬🇧🇮🇪University of Ulster; University College Cork
- JJ Strain🇬🇧🇮🇪University of Ulster; University College Cork
- Julie M W Wallace🇬🇧🇮🇪University of Ulster; University College Cork
- Mairead E Kiely🇬🇧🇮🇪University of Ulster; University College Cork
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Knowledge gaps have contributed to considerable variation among international dietary recommendations for vitamin D.
Objective
We aimed to establish the distribution of dietary vitamin D required to maintain serum 25-hydroxyvitamin D [25(OH)D] concentrations above several proposed cutoffs (ie, 25, 37.5, 50, and 80 nmol/L) during wintertime after adjustment for the effect of summer sunshine exposure and diet.
Design
A randomized, placebo-controlled, double-blind 22-wk intervention study was conducted in men and women aged 20-40 y (n = 238) by using different supplemental doses (0, 5, 10, and 15 microg/d) of vitamin D(3) throughout the winter. Serum 25(OH)D concentrations were measured by using enzyme-linked immunoassay at baseline (October 2006) and endpoint (March 2007).
Results
There were clear dose-related increments (P 25 nmol/L in 97.5% of the sample was 8.7 microg/d. This intake ranged from 7.2 microg/d in those who enjoyed sunshine exposure, 8.8 microg/d in those who sometimes had sun exposure, and 12.3 microg/d in those who avoided sunshine. Vitamin D intakes required to maintain serum 25(OH)D concentrations of >37.5, >50, and >80 nmol/L in 97.5% of the sample were 19.9, 28.0, and 41.1 microg/d, respectively.
Conclusion
The range of vitamin D intakes required to ensure maintenance of wintertime vitamin D status [as defined by incremental cutoffs of serum 25(OH)D] in the vast majority (>97.5%) of 20-40-y-old adults, considering a variety of sun exposure preferences, is between 7.2 and 41.1 microg/d.
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