Long-term creatine supplementation is safe in aged patients with Parkinson disease
Bender A, Samtleben W, Elstner M, Klopstock T
Nutrition research (New York, N.Y.) · 53 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2008-03-01 · Nutr Res · vol. 28 · número 3 · págs. 172–178
- Editorial
- Elsevier BV
- Citado
- 79 citas · más que el 85% de estudios similares · 2.1× el promedio de su campo
- Referencias
- 31 trabajos
- Acceso
- De pago
- Áreas de investigación
- Muscle metabolism and nutrition · Parkinson's Disease Mechanisms and Treatments · Biochemical effects in animals
- Palabras clave
- creatine supplementation, Parkinson's disease, elderly patients, renal function, serum creatinine, cystatin C, gastrointestinal adverse effects, long-term safety, neurodegenerative diseases, weight gain
- MeSH
- kidney, humans, parkinson disease, creatine, neuroprotective agents, kidney function tests, treatment outcome, multivariate analysis, follow-up studies, safety, dose-response relationship, drug, time factors, dietary supplements, middle aged, female, male
4 autores
- Andreas Bender🇩🇪 · autor de correspondenciaLudwig-Maximilians-Universität München
- W. Samtleben🇩🇪Ludwig-Maximilians-Universität München
- Matthias Elstner🇩🇪Ludwig-Maximilians-Universität München
- Thomas Klopstock🇩🇪Ludwig-Maximilians-Universität München
Resumen
El texto original del estudio, en el idioma en que se publicó.
The food supplement creatine (Cr) is widely used by athletes as a natural ergogenic compound. It has also been increasingly tested in neurodegenerative diseases as a potential neuroprotective agent. Weight gain is the most common side effect of Cr, but sporadic reports about the impairment of renal function cause the most concerns with regard to its long-term use. Data from randomized controlled trials on renal function in Cr-supplemented patients are scarce and apply mainly to healthy young athletes. We systematically evaluated potential side effects of Cr with a special focus on renal function in aged patients with Parkinson disease as well as its current use in clinical medical research. Sixty patients with Parkinson disease received either oral Cr (n = 40) or placebo (n = 20) with a dose of 4 g/d for a period of 2 years. Possible side effects as indicated by a broad range of laboratory blood and urine tests were evaluated during 6 follow-up study visits. Overall, Cr was well tolerated. Main side effects were gastrointestinal complaints. Although serum creatinine levels increased in Cr patients because of the degradation of Cr, all other markers of tubular or glomerular renal function, especially cystatin C, remained normal, indicating unaltered kidney function. The data in this trial provide a thorough analysis and give a detailed overview about the safety profile of Cr in older age patients.
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