Effect of fish oil on arrhythmias and mortality: systematic review
León H, Shibata MC, Sivakumaran S, Dorgan M, Chatterley T, Tsuyuki RT
BMJ (Clinical research ed.) · 139 citas
Cómo se estudió
- Diseño
- Revisión sistemática (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Aarhus Universitet
- Universidad u hospital
- Aarhus Universitetshospital
- Universidad u hospital
- University of Alberta
- Organización sin fines de lucro
- Fondation pour la Recherche Médicale
Según 4 financiadores declarados.
Publicación
- Publicado
- 2008-12-23 · BMJ · vol. 337 · número dec23 2 · pág. a2931
- Citado
- 223 citas · más que el 90% de estudios similares · 2.7× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 32 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY-NC
- Áreas de investigación
- Fatty Acid Research and Health · Cardiac electrophysiology and arrhythmias · Cardiac Health and Mental Health
- Palabras clave
- fish oil, docosahexaenoic acid, eicosapentaenoic acid, omega-3 fatty acids, dietary supplements, cardiac arrhythmias, sudden cardiac death, implantable cardioverter-defibrillator, all-cause mortality, cardiovascular mortality, coronary artery disease, myocardial infarction, dose-response relationship, supplement formulation
- MeSH
- humans, docosahexaenoic acids, eicosapentaenoic acid, fish oils, dietary supplements, arrhythmias, cardiac, randomized controlled trials as topic
6 autores
- Hernando León🇨🇦University of Alberta
- Marcelo Coelho Shibata🇨🇦University of Alberta
- Soori T. Sivakumaran🇨🇦University of Alberta
- Marlene Dorgan🇨🇦University of Alberta; Institute of Health Economics
- Trish Chatterley🇨🇦University of Alberta; Institute of Health Economics
- Ross T. Tsuyuki🇨🇦 · autor de correspondenciaUniversity of Alberta
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
To synthesise the literature on the effects of fish oil-docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA)-on mortality and arrhythmias and to explore dose response and formulation effects.
Design
Systematic review and meta-analysis.
Data sources
Medline, Embase, the Cochrane Library, PubMed, CINAHL, IPA, Web of Science, Scopus, Pascal, Allied and Complementary Medicine, Academic OneFile, ProQuest Dissertations and Theses, Evidence-Based Complementary Medicine, and LILACS. Studies reviewed Randomised controlled trials of fish oil as dietary supplements in humans.
Data extraction
The primary outcomes of interest were the arrhythmic end points of appropriate implantable cardiac defibrillator intervention and sudden cardiac death. The secondary outcomes were all cause mortality and death from cardiac causes. Subgroup analyses included the effect of formulations of EPA and DHA on death from cardiac causes and effects of fish oil in patients with coronary artery disease or myocardial infarction.
Data synthesis
12 studies totalling 32 779 patients met the inclusion criteria. A neutral effect was reported in three studies (n=1148) for appropriate implantable cardiac defibrillator intervention (odds ratio 0.90, 95% confidence interval 0.55 to 1.46) and in six studies (n=31 111) for sudden cardiac death (0.81, 0.52 to 1.25). 11 studies (n=32 439 and n=32 519) provided data on the effects of fish oil on all cause mortality (0.92, 0.82 to 1.03) and a reduction in deaths from cardiac causes (0.80, 0.69 to 0.92). The dose-response relation for DHA and EPA on reduction in deaths from cardiac causes was not significant.
Conclusions
Fish oil supplementation was associated with a significant reduction in deaths from cardiac causes but had no effect on arrhythmias or all cause mortality. Evidence to recommend an optimal formulation of EPA or DHA to reduce these outcomes is insufficient. Fish oils are a heterogeneous product, and the optimal formulations for DHA and EPA remain unclear.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC).
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