Prevention of postoperative hypocalcemia with routine oral calcium and vitamin D supplements in patients with differentiated papillary thyroid carcinoma undergoing total thyroidectomy plus central neck dissection
Roh JL, Park JY, Park CI
Cancer · 104 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2008-12-31 · Cancer · vol. 115 · número 2 · págs. 251–258
- Editorial
- Wiley
- Citado
- 157 citas · más que el 99% de estudios similares · 11.3× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 24 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Thyroid and Parathyroid Surgery · Parathyroid Disorders and Treatments · Thyroid Cancer Diagnosis and Treatment
- Palabras clave
- postoperative hypocalcemia, papillary thyroid carcinoma, total thyroidectomy, central neck dissection, oral calcium supplementation, vitamin D supplementation, parathyroid hormone, serum calcium, hypercalcemia
- MeSH
- humans, thyroid neoplasms, hypocalcemia, postoperative complications, calcium, parathyroid hormone, vitamin d, thyroidectomy, neck dissection, administration, oral, dietary supplements, adult, aged, middle aged, female, male
3 autores
- Jong‐Lyel Roh🇰🇷 · autor de correspondenciaAsan Medical Center; University of Ulsan
- Jae‐Yong Park🇰🇷Chungnam National University
- Chanil Park🇰🇷Chungnam National University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Routine oral calcium and vitamin D supplementation may prevent hypocalcemic crisis, but its efficacy has not been studied in patients undergoing thyroidectomy plus central neck dissection (CND). The authors therefore prospectively evaluated the clinical usefulness of routine oral calcium and vitamin D supplementation for prevention of hypocalcemia after total thyroidectomy and CND.
Methods
Of 197 patients with differentiated papillary thyroid carcinoma, 49 underwent total thyroidectomy alone, and 148 underwent total thyroidectomy plus CND. The latter were randomized to oral calcium (3 g/day) plus vitamin D (1 mg/day) (Group A, n=49), calcium alone (Group B, n=49), or no supplements (Group C, n=50). Hypocalcemic symptoms, serum calcium, and parathyroid hormone (PTH) levels were compared among the groups.
Results
Group C had significantly higher incidences of symptomatic (26.0% vs 6.1%; P<.015) and laboratory (44.0% vs 14.3%; P<.015) hypocalcemia than the group without CND. The incidences of symptomatic and laboratory hypocalcemia were significantly decreased in Groups A (2.0% and 8.2%, respectively) and B (12.2% and 24.5%, respectively) (P<.05). Serum calcium levels decreased in most patients after surgery, but recovered earliest in Group A. Hypercalcemia and PTH inhibition did not occur in gs A and B.
Conclusions
Compared with total thyroidectomy alone, CND significantly increases the rate of postoperative hypocalcemia, which can be prevented by routine postoperative supplementation with oral calcium and vitamin D.
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