Cruciferous vegetable consumption and lung cancer risk: a systematic review
Lam TK, Gallicchio L, Lindsley K, Shiels M, Hammond E, Tao XG, Chen L, Robinson KA, Caulfield LE, Herman JG, Guallar E, Alberg AJ
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 131 citas
Cómo se estudió
- Diseño
- Revisión sistemática (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
- Organización sin fines de lucro
- American Institute for Cancer Research
- Gobierno
- National Institutes of Health
- Gobierno
- Intramural NIH HHS
- Subvenciones
- National Institutes of Health (Z99 CA999999)
Según 3 financiadores declarados.
Publicación
- Publicado
- 2009-01-01 · Cancer Epidemiol Biomarkers Prev · vol. 18 · número 1 · págs. 184–195
- Editorial
- American Association for Cancer Research
- Citado
- 219 citas · más que el 62% de estudios similares · 0.8× el promedio de su campo
- Referencias
- 76 trabajos
- Acceso
- Acceso abierto (copia en repositorio)
- Áreas de investigación
- Glutathione Transferases and Polymorphisms · Genomics, phytochemicals, and oxidative stress · Nutritional Studies and Diet
- Palabras clave
- cruciferous vegetables, lung cancer risk, isothiocyanates, glutathione S-transferase, GSTM1, GSTT1, gene-diet interaction, dietary intake, chemoprevention
- MeSH
- humans, brassicaceae, vegetables, lung neoplasms, glutathione transferase, diet, risk, genotype
12 autores
- Tram Kim Lam🇺🇸National Institutes of Health; National Cancer Institute
- Lisa M. Gallicchio🇺🇸Mercy Medical Center
- Kristina B. Lindsley
- Meredith S. Shiels
- Edward R. Hammond
- Xuguang Grant Tao
- Liwei Chen🇺🇸Johns Hopkins University
- Karen A. Robinson
- Laura E. Caulfield🇺🇸Johns Hopkins University
- James Gordon Herman🇺🇸Johns Hopkins University; Johns Hopkins Medicine
- Eliseo Güallar
- Anthony J. Alberg🇺🇸Medical University of South Carolina; MUSC Hollings Cancer Center
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Cruciferous vegetables, rich in isothiocyanates, may protect against lung cancer. Glutathione S-transferases are important in metabolizing isothiocyanates; hence, variants in GST genes may modify the association between cruciferous vegetable intake and lung cancer. We carried out a systematic review to characterize the association between cruciferous vegetable intake and lung cancer risk, with an emphasis on the potential interaction between cruciferous vegetables and GSTM1 and GSTT1 gene variants.
Methods
A search of the epidemiologic literature through December 2007 was conducted using 15 bibliographic databases without language restrictions. Thirty studies on the association between lung cancer and either total cruciferous vegetable consumption (6 cohort and 12 case-control studies) or specific cruciferous vegetables (1 cohort and 11 case-control studies) were included.
Results
The risk for lung cancer among those in the highest category of total cruciferous vegetable intake was 22% lower in case-control studies [random-effects pooled odds ratio, 0.78; 95% confidence interval (95% CI), 0.70-0.88] and 17% lower in cohort studies (pooled relative risk, 0.83; 95% CI, 0.62-1.08) compared with those in the lowest category of intake. The strongest inverse association of total cruciferous vegetable intake with lung cancer risk was seen among individuals with GSTM1 and GSTT1 double null genotypes (odds ratio, 0.41; 95% CI, 0.26-0.65; P for interaction = 0.01).
Conclusions
Epidemiologic evidence suggests that cruciferous vegetable intake may be weakly and inversely associated with lung cancer risk. Because of a gene-diet interaction, the strongest inverse association was among those with homozygous deletion for GSTM1 and GSTT1.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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