Effect of fish oil on ventricular tachyarrhythmia in three studies in patients with implantable cardioverter defibrillators
Brouwer IA, Raitt MH, Dullemeijer C, Kraemer DF, Zock PL, Morris C, Katan MB, Connor WE, Camm JA, Schouten EG, McAnulty J
European heart journal · 86 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- European Commission
- Gobierno
- National Institutes of Health
- Gobierno
- National Heart, Lung, and Blood Institute
- Gobierno
- National Center for Research Resources
- Gobierno
- NHLBI NIH HHS
- Gobierno
- NCRR NIH HHS
- Subvenciones
- National Heart, Lung, and Blood Institute (R01HL61682); National Center for Research Resources (5M01 RR00334)
Según 6 financiadores declarados.
Publicación
- Publicado
- 2008-12-09 · Eur Heart J · vol. 30 · número 7 · págs. 820–826
- Editorial
- Oxford University Press
- Citado
- 121 citas · más que el 99% de estudios similares · 10.8× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 57 trabajos
- Acceso
- Acceso abierto (copia en repositorio)
- Áreas de investigación
- Fatty Acid Research and Health · Cardiac electrophysiology and arrhythmias · Cardiac pacing and defibrillation studies
- Palabras clave
- fish oil, omega-3 polyunsaturated fatty acids, ventricular tachyarrhythmia, ventricular fibrillation, implantable cardioverter-defibrillator, recurrent arrhythmia, coronary artery disease
- MeSH
- humans, tachycardia, ventricular, fatty acids, omega-3, treatment outcome, prospective studies, defibrillators, implantable, dietary supplements, aged, middle aged, female, male, heart failure, randomized controlled trials as topic, secondary prevention
11 autores
- Ingeborg A. Brouwer🇳🇱 · autor de correspondenciaTiFN; Vrije Universiteit Amsterdam
- Merritt H. Raitt🇺🇸Portland VA Medical Center
- Carla Dullemeijer🇳🇱TiFN; Wageningen University & Research
- Dale F. Kraemer🇺🇸Oregon State University; Oregon Health & Science University
- Peter L. Zock
- Cynthia D. Morris🇺🇸Oregon Health & Science University
- Mira Katan🇳🇱Vrije Universiteit Amsterdam
- WILLIAM E. CONNOR🇺🇸Oregon Health & Science University
- A. John Camm🇬🇧St George's, University of London
- Evert G. Schouten🇳🇱TiFN; Wageningen University & Research
- John H. McAnulty🇺🇸Legacy Good Samaritan Medical Center
Resumen
El texto original del estudio, en el idioma en que se publicó.
Aims
To determine the effects of omega-3 polyunsaturated fatty acids (omega-3 PUFAs) from fish on the incidence of recurrent ventricular arrhythmia in implantable cardioverter defibrillator (ICD) patients by combining results from published trials.
Methods and results
We searched in the Medline, EMBASE, and Cochrane databases and performed a meta-analysis on all three available trials on fish oil and ventricular arrhythmia. Furthermore, we pooled individual data of two of these randomized, double-blind, placebo-controlled trials (Raitt et al. Fish oil supplementation and risk of ventricular tachycardia and ventricular fibrillation in patients with implantable defibrillators: a randomized controlled trial. JAMA 2005;293:2884-2891 and Brouwer et al. Effect of fish oil on ventricular tachyarrhythmia and death in patients with implantable cardioverter defibrillators: the Study on Omega-3 Fatty Acids and Ventricular Arrhythmia (SOFA) randomized trial. JAMA 2006;295:2613-2619). The main outcome was time to first confirmed ventricular fibrillation (VF) or ventricular tachycardia (VT) combined with death for the meta-analysis, and time to first spontaneous confirmed VF or VT for the pooled analysis. The meta-analysis (n = 1148) showed no convincing protective effect of fish oil (RR 0.90; 95% CI 0.67-1.22). The hazard ratio for the subgroup of patients with coronary artery disease at baseline (0.79; 0.60-1.06) tended towards a protective effect. The pooled analysis (n = 722) showed that time to appropriate ICD intervention was similar for fish oil and placebo treatment (log-rank P = 0.79).
Conclusion
These findings do not support a protective effect of omega-3 PUFAs from fish oil on cardiac arrhythmia in all patients with an ICD. Current data neither prove nor disprove a beneficial or a detrimental effect for subgroups of patients with specific underlying pathologies.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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