Glucose and insulin responses to whole grain breakfasts varying in soluble fiber, beta-glucan: a dose response study in obese women with increased risk for insulin resistance
Kim H, Stote KS, Behall KM, Spears K, Vinyard B, Conway JM
European journal of nutrition · 57 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- Comida provista por los investigadores
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2009-02-05 · Eur J Nutr · vol. 48 · número 3 · págs. 170–175
- Editorial
- Springer Science+Business Media
- Citado
- 94 citas · más que el 98% de estudios similares · 9.3× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 31 trabajos
- Acceso
- De pago
- Áreas de investigación
- Food composition and properties · Natural Antidiabetic Agents Studies · Microbial Metabolites in Food Biotechnology
- Palabras clave
- β-glucan, soluble dietary fiber, postprandial glucose response, insulin response, wheat, barley, obesity, insulin resistance, glycemic response
- MeSH
- humans, hordeum, diabetes mellitus, type 2, insulin resistance, obesity, insulin, blood glucose, beta-glucans, glucose tolerance test, body mass index, risk factors, cross-over studies, energy intake, dose-response relationship, drug, dietary fiber, middle aged, female, edible grain
6 autores
- Hyunsook Kim🇺🇸 · autor de correspondenciaAgricultural Research Service; Western Regional Research Center
- Kim S. Stote🇺🇸Agricultural Research Service; Beltsville Human Nutrition Research Center; Beltsville Agricultural Research Center
- Kay M. Behall🇺🇸Agricultural Research Service; Beltsville Human Nutrition Research Center; Beltsville Agricultural Research Center
- Karen E. Spears🇺🇸University of Nevada, Reno
- Bryan T. Vinyard🇺🇸Agricultural Research Service; United States Department of Agriculture; Beltsville Agricultural Research Center; Agricultural Research Service - Northeast Area
- Joan Marie Conway🇺🇸Agricultural Research Service; Beltsville Human Nutrition Research Center; Beltsville Agricultural Research Center
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
A high intake of whole grains containing soluble fiber has been shown to lower glucose and insulin responses in overweight humans and humans with type 2 diabetes.
Aim of the study
We investigated the linearity of this response after consumption of 5 breakfast cereal test meals containing wheat and/or barley to provide varying amounts of soluble fiber, beta-glucan (0, 2.5, 5, 7.5 and 10 g).
Methods
Seventeen normoglycemic, obese women at increased risk for insulin resistance consumed 5 test meals within a randomized cross-over design after consuming controlled diets for 2 days. Blood samples for glucose and insulin response were obtained prior to and 30, 60, 120 and 180 min after consuming the test meals.
Results
Consumption of 10 g of beta-glucan significantly reduced peak glucose response at 30 min and delayed the rate of glucose response. Area under the curve for 2 h-postprandial glycemic response was not affected by beta-glucan content. However, peak and area under the curve of insulin responses were significantly affected by the beta-glucan amount in an inverse linear relationship.
Conclusion
These data suggest that acute consumption of 10 g of beta-glucan is able to induce physiologically beneficial effects on postprandial insulin responses in obese women at risk for insulin resistance.
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