Calcium plus vitamin D supplementation and mortality in postmenopausal women: the Women's Health Initiative calcium-vitamin D randomized controlled trial
LaCroix AZ, Kotchen J, Anderson G, Brzyski R, Cauley JA, Cummings SR, Gass M, Johnson KC, Ko M, Larson J, Manson JE, Stefanick ML, Wactawski-Wende J
The journals of gerontology. Series A, Biological sciences and medical sciences · 142 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Heart, Lung, and Blood Institute
- Gobierno
- NIH Clinical Center
Según 2 financiadores declarados.
Publicación
- Publicado
- 2009-02-16 · J Gerontol A Biol Sci Med Sci · vol. 64A · número 5 · págs. 559–567
- Editorial
- Oxford University Press
- Citado
- 217 citas · más que el 100% de estudios similares · 17.5× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 37 trabajos
- Acceso
- Acceso abierto (copia en repositorio)
- Áreas de investigación
- Vitamin D Research Studies · Bone health and osteoporosis research · Nutrition and Health Studies
- Palabras clave
- calcium supplementation, vitamin D supplementation, postmenopausal women, all-cause mortality, cause-specific mortality, stroke mortality, cancer mortality, coronary heart disease mortality, age interaction, medication adherence, Women's Health Initiative, calcium carbonate, vitamin D3
- MeSH
- humans, calcium, vitamin d, treatment outcome, drug therapy, combination, mortality, postmenopause, dietary supplements, aged, aged, 80 and over, middle aged, women's health, female, bone density conservation agents
13 autores
- Andrea Z. LaCroix🇺🇸Fred Hutch Cancer Center; Women's Health Initiative
- Jane Morley Kotchen🇺🇸Medical College of Wisconsin
- Garnet L. Anderson🇺🇸Fred Hutch Cancer Center
- Robert G. Brzyski🇺🇸The University of Texas at San Antonio Health Science Center
- Jane A. Cauley🇺🇸University of Pittsburgh
- Steven Ron Cummings🇺🇸University of California, San Francisco
- Margery L S Gass🇺🇸University of Cincinnati
- Karen Johnson🇺🇸University of Tennessee Health Science Center
- M. Ko🇺🇸Mayo Clinic; Mayo Clinic in Arizona
- Joseph C. Larson🇺🇸Fred Hutch Cancer Center
- JoAnn E. Manson🇺🇸Brigham and Women's Hospital; Harvard University
- Marcia L. Stefanick🇺🇸Stanford University
- Jean Wactawski‐Wende🇺🇸University at Buffalo, State University of New York
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Calcium and vitamin D (CaD) supplementation trials including the Women's Health Initiative (WHI) trial of CaD have shown nonsignificant reductions in total mortality. This report examines intervention effects on total and cause-specific mortality by age and adherence.
Methods
The WHI CaD trial was a randomized, double-blind, placebo-controlled trial that enrolled 36,282 postmenopausal women aged 51-82 years from 40 U.S. clinical centers. Women were assigned to 1,000 mg of elemental calcium carbonate and 400 IU of vitamin D(3) daily or placebo with average follow-up of 7.0 years.
Results
The hazard ratio (HR) for total mortality was 0.91 (95% confidence interval [CI], 0.83-1.01) with 744 deaths in women randomized to CaD versus 807 deaths in the placebo group. HRs were in the direction of reduced risk but nonsignificant for stroke and cancer mortality, but near unity for coronary heart disease and other causes of death. HRs for total mortality were 0.89 in the 29,942 women younger than 70 years (95% CI, 0.79-1.01) and 0.95 in the 6,340 women aged 70 and older (95% CI, 0.80-1.12; p value for age interaction = .10). No statistically significant interactions were observed for any baseline characteristics. Treatment effects did not vary significantly by season.
Conclusions
In the WHI CaD trial, supplementation did not have a statistically significant effect on mortality rates but the findings support the possibility that these supplements may reduce mortality rates in postmenopausal women. These data can neither support nor refute recommendations for higher dose vitamin D supplementation to reduce cancer or total mortality.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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