Effect of broccoli intake on markers related to oxidative stress and cancer risk in healthy smokers and nonsmokers
Riso P, Martini D, Visioli F, Martinetti A, Porrini M
Nutrition and cancer · 40 citas
Etiquetas de revisión
Alimentación controladaFinanciación no declaradaSolo mecanismosDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Solo mecanismos
- Consumo medido con
- Comida provista por los investigadores
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2009-02-21 · Nutr Cancer · vol. 61 · número 2 · págs. 232–237
- Editorial
- Routledge
- Citado
- 66 citas · más que el 89% de estudios similares · 2.4× el promedio de su campo
- Referencias
- 32 trabajos
- Acceso
- De pago
- Áreas de investigación
- Genomics, phytochemicals, and oxidative stress · Phytochemicals and Antioxidant Activities · Antioxidant Activity and Oxidative Stress
- Palabras clave
- broccoli, cruciferous vegetables, oxidative stress, DNA damage, smokers, non-smokers, histone deacetylase, insulin-like growth factor I, oxidized purines, cancer risk, dietary intervention, lymphocytes, strand breaks
- MeSH
- lymphocytes, humans, brassica, neoplasms, dna damage, hydrogen peroxide, histone deacetylases, insulin-like growth factor i, anticarcinogenic agents, comet assay, diet, cross-over studies, smoking, oxidative stress, adult, male, biomarkers
5 autores
- Patrizia Riso🇮🇹University of Milan
- Daniela Martini🇮🇹University of Milan
- Francesco Visioli🇫🇷Université Pierre-et-Marie-Curie
- Antonia Martinetti🇮🇹Fondazione IRCCS Istituto Nazionale dei Tumori
- Marisa Porrini🇮🇹University of Milan
Resumen
El texto original del estudio, en el idioma en que se publicó.
Cruciferous vegetables (CVs) have been widely studied for their anticarcinogenic properties. The aim of the present study was to evaluate the protective effect of broccoli intake in smokers and nonsmokers. Twenty young healthy males (10 smokers and 10 nonsmokers) were randomized in a cross-over design and received a portion of broccoli (200 g) or maintained a controlled diet for 10 days each. The two periods were separated by a wash-out period (20 days). Blood samples were collected at 0, 10, 30, and 40 days and used for the evaluation of DNA damage, insulin-like growth factor-I (IGF-I) and histone deacetylase (HDAC). Ex vivo protection from H(2)O(2)-induced DNA damage and endogenous DNA damage were evaluated in lymphocytes by means of the comet assay. Strand breaks decreased significantly after the broccoli diet in smokers as well as in nonsmokers (-22.2%; P < 0.0001), whereas oxidized purines decreased significantly only in smokers (-51.0%; P < 0.0001). Broccoli intake did not modify HDAC activity and IGF-I serum levels. Our results strengthen the importance of consuming CVs to increase cell protection against DNA damage. Future investigation, with different amount of broccoli and/or different time of exposure, is needed to understand the lack of effect on HDAC activity and IGF-I levels.
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