Sustaining executive functions during sleep deprivation: A comparison of caffeine, dextroamphetamine, and modafinil
Killgore WD, Kahn-Greene ET, Grugle NL, Killgore DB, Balkin TJ
Sleep · 79 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- U.S. Department of Defense
Según 1 financiador declarado.
Publicación
- Publicado
- 2009-02-01 · Sleep · vol. 32 · número 2 · págs. 205–216
- Editorial
- Oxford University Press
- Citado
- 132 citas · más que el 99% de estudios similares · 14.9× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 78 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Sleep and Work-Related Fatigue · Sleep and Wakefulness Research · Coffee research and impacts
- Palabras clave
- sleep deprivation, executive function, caffeine, d-amphetamine, modafinil, stimulant medication, cognitive performance, Tower of Hanoi, Tower of London, Wisconsin Card Sorting Test, perseverative responding, planning, decision-making
- MeSH
- humans, sleep deprivation, dextroamphetamine, benzhydryl compounds, caffeine, central nervous system stimulants, double-blind method, discrimination learning, problem solving, pattern recognition, visual, decision making, psychomotor performance, arousal, attention, cognition disorders, neuropsychological tests, dose-response relationship, drug, adolescent, adult, female, male, young adult, modafinil
5 autores
- William D. S. Killgore🇺🇸 · autor de correspondenciaWalter Reed Army Institute of Research
- Ellen T. Kahn-Greene🇺🇸Walter Reed Army Institute of Research
- Nancy L. Grugle🇺🇸Walter Reed Army Institute of Research
- Desiree B. Killgore🇺🇸Walter Reed Army Institute of Research
- Thomas J. Balkin🇺🇸Walter Reed Army Institute of Research
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objectives
Stimulant medications appear effective at restoring simple alertness and psychomotor vigilance in sleep deprived individuals, but it is not clear whether these medications are effective at restoring higher order complex cognitive capacities such as planning, sequencing, and decision making.
Design
After 44 hours awake, participants received a double-blind dose of one of 3 stimulant medications or placebo. After 45-50 hours awake, participants were tested on computerized versions of the 5-Ring Tower of Hanoi (TOH), the Tower of London (TOL), and the Wisconsin Card Sorting Test (WCST).
Setting
In-residence sleep-laboratory facility at the Walter Reed Army Institute of Research.
Participants
Fifty-four healthy adults (29 men, 25 women), ranging in age from 18 to 36 years.
Interventions
Participants were randomly assigned to 1 of 3 stimulant medication groups, including caffeine, 600 mg (n=12), modafinil, 400 mg (n=12), dextroamphetamine, 20 mg (n=16), or placebo (n=14).
Measurements and results
At the doses tested, modafinil and dextroamphetamine groups completed the TOL task in significantly fewer moves than the placebo group, and the modafinil group demonstrated greater deliberation before making moves. In contrast, subjects receiving caffeine completed the TOH in fewer moves than all 3 of the other groups, although speed of completion was not influenced by the stimulants. Finally, the modafinil group outperformed all other groups on indices of perseverative responding and perseverative errors from the WCST.
Conclusions
Although comparisons across tasks cannot be made due to the different times of administration, within-task comparisons suggest that, at the doses tested here, each stimulant may produce differential advantages depending on the cognitive demands of the task.
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