Creatine fails to augment the benefits from resistance training in patients with HIV infection: a randomized, double-blind, placebo-controlled study
Sakkas GK, Mulligan K, Dasilva M, Doyle JW, Khatami H, Schleich T, Kent-Braun JA, Schambelan M
PloS one · 19 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Deutsches Krebsforschungszentrum
- Gobierno
- National Institutes of Health
- Gobierno
- National Institute of Diabetes and Digestive and Kidney Diseases
- Gobierno
- National Center for Complementary and Alternative Medicine
- Gobierno
- National Center for Research Resources
- Gobierno
- National Center for Complementary and Integrative Health
- Gobierno
- NCCIH NIH HHS
- Gobierno
- NIDDK NIH HHS
- Gobierno
- NCRR NIH HHS
- Subvenciones
- National Institute of Diabetes and Digestive and Kidney Diseases (DK 54615); National Center for Complementary and Integrative Health (AT00491); National Institute of Diabetes and Digestive and Kidney Diseases (R01 DK054615); National Center for Research Resources (M01-RR000083); National Institute of Diabetes and Digestive and Kidney Diseases (DK-45833); National Center for Research Resources (RR 00083); National Center for Complementary and Integrative Health (R01 AT000491); National Institutes of Health (AT00491); National Institutes of Health (DK54615); National Institutes of Health (DK45833); National Institutes of Health (RR-00083)
Según 9 financiadores declarados.
Publicación
- Publicado
- 2009-02-25 · PLoS One · vol. 4 · número 2 · pág. e4605
- Editorial
- Public Library of Science
- Citado
- 45 citas · más que el 75% de estudios similares · 1.2× el promedio de su campo
- Referencias
- 59 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Muscle metabolism and nutrition · HIV-related health complications and treatments · Nutrition and Health in Aging
- Palabras clave
- creatine supplementation, resistance training, HIV infection, muscle strength, muscle energetics, lean body mass, body composition, muscle cross-sectional area, progressive resistance training
- MeSH
- humans, hiv infections, creatine, treatment outcome, double-blind method, body composition, physical endurance, adult, middle aged, san francisco, male, muscle strength, resistance training
8 autores
- Giorgos K. Sakkas🇺🇸🇬🇷San Francisco General Hospital; University of Thessaly; University of California, San Francisco
- Kathleen M. Mulligan🇺🇸San Francisco General Hospital; University of California, San Francisco
- Makani DaSilva🇺🇸San Francisco General Hospital
- Julie Doyle🇺🇸Northern California Institute for Research and Education
- Hootan Khatami🇺🇸San Francisco General Hospital
- Thomas Schleich🇺🇸University of California, Santa Cruz
- Jane A. Kent‐Braun🇺🇸University of Massachusetts Amherst
- Morris Schambelan🇺🇸 · autor de correspondenciaSan Francisco General Hospital; University of California, San Francisco
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Progressive resistance exercise training (PRT) improves physical functioning in patients with HIV infection. Creatine supplementation can augment the benefits derived from training in athletes and improve muscle function in patients with muscle wasting. The objective of this study was to determine whether creatine supplementation augments the effects of PRT on muscle strength, energetics, and body composition in HIV-infected patients.
Methodology/principal findings
This is a randomized, double blind, placebo-controlled, clinical research center-based, outpatient study in San Francisco. 40 HIV-positive men (20 creatine, 20 placebo) enrolled in a 14-week study. Subjects were randomly assigned to receive creatine monohydrate or placebo for 14 weeks. Treatment began with a loading dose of 20 g/day or an equivalent number of placebo capsules for 5 days, followed by maintenance dosing of 4.8 g/day or placebo. Beginning at week 2 and continuing to week 14, all subjects underwent thrice-weekly supervised resistance exercise while continuing on the assigned study medication (with repeated 6-week cycles of loading and maintenance). The main outcome measurements included muscle strength (one repetition maximum), energetics ((31)P magnetic resonance spectroscopy), composition and size (magnetic resonance imaging), as well as total body composition (dual-energy X-ray absorptiometry). Thirty-three subjects completed the study (17 creatine, 16 placebo). Strength increased in all 8 muscle groups studied following PRT, but this increase was not augmented by creatine supplementation (average increase 44 vs. 42%, difference 2%, 95% CI -9.5% to 13.9%) in creatine and placebo, respectively). There were no differences between groups in changes in muscle energetics. Thigh muscle cross-sectional area increased following resistance exercise, with no additive effect of creatine. Lean body mass (LBM) increased to a significantly greater extent with creatine. CONCLUSIONS / SIGNIFICANCE: Resistance exercise improved muscle size, strength and function in HIV-infected men. While creatine supplementation produced a greater increase in LBM, it did not augment the robust increase in strength derived from PRT.
Trial registration
ClinicalTrials.gov NCT00484627.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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