Effects of vitamin D and calcium supplementation on markers of apoptosis in normal colon mucosa: a randomized, double-blind, placebo-controlled clinical trial
Fedirko V, Bostick RM, Flanders WD, Long Q, Shaukat A, Rutherford RE, Daniel CR, Cohen V, Dash C
Cancer prevention research (Philadelphia, Pa.) · 94 citas
Etiquetas de revisión
Solo mecanismosDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Solo mecanismos
Quién lo pagó
- Financiación
- Financiación independiente
- Organización sin fines de lucro
- Georgia Cancer Coalition
- Universidad u hospital
- Emory University
- Gobierno
- National Institutes of Health
- Gobierno
- National Cancer Institute
- Gobierno
- NCI NIH HHS
- Subvenciones
- National Cancer Institute (R01CA104637)
Según 5 financiadores declarados.
Publicación
- Publicado
- 2009-03-01 · Cancer Prev Res (Phila) · vol. 2 · número 3 · págs. 213–223
- Editorial
- American Association for Cancer Research
- Citado
- 143 citas · más que el 99% de estudios similares · 10.1× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 61 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Vitamin D Research Studies · Nutritional Studies and Diet · Colorectal Cancer Screening and Detection
- Palabras clave
- vitamin D3, calcium supplementation, colorectal cancer chemoprevention, apoptosis, Bax, Bcl-2, colorectal mucosa, colorectal adenoma
- MeSH
- intestinal mucosa, colon, humans, adenoma, colorectal neoplasms, calcium, cholecalciferol, vitamin d, placebos, immunohistochemistry, double-blind method, apoptosis, dietary supplements, adult, aged, middle aged, female, male
9 autores
- Veronika Fedirko🇺🇸University of Minnesota; Emory University; Winship Cancer Institute
- Roberd M. Bostick🇺🇸 · autor de correspondenciaUniversity of Minnesota; Emory University; Winship Cancer Institute
- W. Dana Flanders🇺🇸University of Minnesota; Emory University; Winship Cancer Institute
- Qi Long🇺🇸University of Minnesota; Emory University; Winship Cancer Institute
- Aasma Shaukat🇺🇸University of Minnesota; Emory University; Winship Cancer Institute
- Robin E. Rutherford🇺🇸University of Minnesota; Emory University; Winship Cancer Institute
- Carrie R. Daniel🇺🇸University of Minnesota; Emory University; Winship Cancer Institute
- Vaunita Cohen🇺🇸University of Minnesota; Emory University; Winship Cancer Institute
- Chiranjeev Dash🇺🇸University of Minnesota; Emory University; Winship Cancer Institute
Resumen
El texto original del estudio, en el idioma en que se publicó.
To further clarify and/or develop calcium and vitamin D as chemopreventive agents against colorectal cancer in humans, understand the mechanisms by which these agents reduce risk for the disease, and develop "treatable" biomarkers of risk for colorectal cancer, we conducted a pilot, randomized, double-blind, placebo-controlled, 2 x 2 factorial clinical trial to test the effects of calcium and vitamin D3, alone and in combination on markers of apoptosis, in the normal colorectal mucosa. Ninety-two men and women with at least one pathology-confirmed colorectal adenoma were treated with 2.0 g/d calcium or 800 IU/d vitamin D3, alone or in combination, versus placebo over 6 months. Overall expression and colorectal crypt distributions of Bcl-2 (an apoptosis inhibitor) and Bax (an apoptosis promoter) in biopsies of normal-appearing rectal mucosa were detected by automated immunohistochemistry and quantified by image analysis. After 6 months of treatment, Bax expression along the full lengths of crypts increased 56% (P = 0.02) in the vitamin D group and 33% in both the calcium (P = 0.31) and calcium plus vitamin D (P = 0.36) groups relative to the placebo group. The vitamin D treatment effect was more pronounced in the upper 40%, or differentiation zone, of crypts (80%; P = 0.01). There were no statistically significant treatment effects on Bcl-2 expression. Overall, these preliminary results suggest that calcium and vitamin D, individually or together, may enhance apoptosis in the normal human colorectal epithelium, and the strongest treatment effects may be vitamin D related and in the upper sections of the colorectal crypts.
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