Fish consumption, long-chain omega-3 fatty acids and risk of cognitive decline or Alzheimer disease: a complex association
Fotuhi M, Mohassel P, Yaffe K
Nature clinical practice. Neurology · 215 citas
Cómo se estudió
- Diseño
- Revisión sistemática (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Institutes of Health
- Gobierno
- National Institute on Aging
- Gobierno
- NIA NIH HHS
- Subvenciones
- National Institute on Aging (AG031155)
Según 3 financiadores declarados.
Publicación
- Publicado
- 2009-03-01 · Nat Clin Pract Neurol · vol. 5 · número 3 · págs. 140–152
- Editorial
- Nature Portfolio
- Citado
- 343 citas · más que el 96% de estudios similares · 3.3× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 82 trabajos
- Acceso
- De pago
- Áreas de investigación
- Fatty Acid Research and Health · Dementia and Cognitive Impairment Research · Alzheimer's disease research and treatments
- Palabras clave
- fish consumption, n-3 long-chain polyunsaturated fatty acids, cognitive decline, Alzheimer's disease, dementia, neuroprotection, omega-3 supplements, omega-6 fatty acids, dementia prevention, clinical trials
- MeSH
- animals, fishes, humans, dementia, alzheimer disease, fatty acids, omega-3, neuroprotective agents, diet, risk factors, cognition, cognition disorders, dietary supplements, clinical trials as topic
3 autores
- Majid Fotuhi🇺🇸 · autor de correspondenciaJohns Hopkins University; Johns Hopkins Medicine; Sinai Hospital; LifeBridge Health
- Payam Mohassel🇺🇸Johns Hopkins University; Johns Hopkins Medicine; LifeBridge Health
- Kristine S. Yaffe🇺🇸San Francisco VA Medical Center; University of California, San Francisco
Resumen
El texto original del estudio, en el idioma en que se publicó.
Long-chain omega-3 fatty acids could have neuroprotective properties against dementia, which is becoming a major global public health issue. We conducted a systematic review of the literature to establish the association between eating fish (a source of long-chain omega-3 fatty acids) or taking long-chain omega-3 fatty acid supplements and the risk of cognitive decline or Alzheimer disease (AD). We identified eleven observational studies and four clinical trials. All three observational studies that used cognitive decline as an outcome reported significant benefits, whereas only four of eight observational studies that used incidence of AD or dementia as an outcome reported positive findings. None of four small clinical trials provided convincing evidence for the use of this approach in the prevention or treatment of any form of dementia. In summary, the existing data favor a role for long-chain omega-3 fatty acids in slowing cognitive decline in elderly individuals without dementia, but not for the prevention or treatment of dementia (including AD). This apparent dichotomy might reflect differences in study designs with regard to participants, dosages, the ratio of long-chain omega-3 to omega-6 fatty acids, or the choice of outcome measurements. Large clinical trials of extended duration should help to provide definitive answers.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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