Estimation of the dietary requirement for vitamin D in free-living adults >=64 y of age
Cashman KD, Wallace JM, Horigan G, Hill TR, Barnes MS, Lucey AJ, Bonham MP, Taylor N, Duffy EM, Seamans K, Muldowney S, Fitzgerald AP, Flynn A, Strain JJ, Kiely M
The American journal of clinical nutrition · 117 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2009-03-19 · Am J Clin Nutr · vol. 89 · número 5 · págs. 1366–1374
- Editorial
- Elsevier BV
- Citado
- 168 citas · más que el 99% de estudios similares · 13.0× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 42 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Vitamin D Research Studies · Nutrition and Health Studies · Vitamin K Research Studies
- Palabras clave
- vitamin D, nutrient requirements, older adults, vitamin D3 supplementation, 25-hydroxyvitamin D, vitamin D deficiency, sun exposure, dose-response relationship
- MeSH
- humans, vitamin d deficiency, calcium, cholecalciferol, parathyroid hormone, vitamin d, double-blind method, sunlight, seasons, nutritional requirements, dietary supplements, aged, female, male
15 autores
- Kevin D. Cashman🇮🇪 · autor de correspondenciaUniversity College Cork
- Julie M W Wallace🇬🇧🇮🇪University of Ulster; University College Cork
- Geraldine Horigan🇬🇧🇮🇪University of Ulster; University College Cork
- Tom R. Hill🇬🇧🇮🇪University of Ulster; University College Cork
- Maria S. Mulhern🇬🇧🇮🇪University of Ulster; University College Cork
- Alice J. Lucey🇬🇧🇮🇪University of Ulster; University College Cork
- Maxine P. Bonham🇬🇧🇮🇪University of Ulster; University College Cork
- Nicola Taylor🇬🇧🇮🇪University of Ulster; University College Cork
- Emeir M. McSorley🇬🇧🇮🇪University of Ulster; University College Cork
- Kelly M. Seamans🇬🇧🇮🇪University of Ulster; University College Cork
- Siobhan Muldowney🇬🇧🇮🇪University of Ulster; University College Cork
- Tony Fitzgerald🇬🇧🇮🇪University of Ulster; University College Cork
- Albert Flynn🇬🇧🇮🇪University of Ulster; University College Cork
- JJ Strain🇬🇧🇮🇪University of Ulster; University College Cork
- Mairead E Kiely🇬🇧🇮🇪University of Ulster; University College Cork
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Older adults may be more prone to developing vitamin D deficiency than younger adults. Dietary requirements for vitamin D in older adults are based on limited evidence.
Objective
The objective was to establish the dietary intake of vitamin D required to maintain serum 25-hydroxyvitamin D [25(OH)D] concentrations above various cutoffs between 25 and 80 nmol/L during wintertime, which accounted for the effect of summer sunshine exposure and diet.
Design
A randomized, placebo-controlled, double-blind, 22-wk intervention was conducted in men and women aged >/=64 y (n = 225) at supplemental levels of 0, 5, 10, and 15 microg vitamin D(3)/d from October 2007 to March 2008.
Results
Clear dose-related increments (P 25 nmol/L in 97.5% of the sample was 8.6 microg/d. Intakes were 7.9 and 11.4 microg/d in those who reported a minimum of 15 min daily summer sunshine exposure or less, respectively. The intakes required to maintain serum 25(OH)D concentrations of >37.5, >50, and >80 nmol/L in 97.5% of the sample were 17.2, 24.7, and 38.7 microg/d, respectively.
Conclusion
To ensure that the vitamin D requirement is met by the vast majority (>97.5%) of adults aged >/=64 y during winter, between 7.9 and 42.8 microg vitamin D/d is required, depending on summer sun exposure and the threshold of adequacy of 25(OH)D. This trial was registered at http://www.controlled-trials.com/ISRCTN20236112 as ISRCTN registration no. ISRCTN20236112.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.