Vitamin D supplementation enhances the beneficial effects of weight loss on cardiovascular disease risk markers
Zittermann A, Frisch S, Berthold HK, Götting C, Kuhn J, Kleesiek K, Stehle P, Koertke H, Koerfer R
The American journal of clinical nutrition · 383 citas
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Cómo se estudió
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- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
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- Resultado principal
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Quién lo pagó
- Financiación
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Publicación
- Publicado
- 2009-03-25 · Am J Clin Nutr · vol. 89 · número 5 · págs. 1321–1327
- Editorial
- Elsevier BV
- Citado
- 558 citas · más que el 100% de estudios similares · 29.0× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 57 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Vitamin D Research Studies · Parathyroid Disorders and Treatments · Nutritional Studies and Diet
- Palabras clave
- vitamin D supplementation, weight loss, cardiovascular risk markers, 25-hydroxyvitamin D, 1,25-dihydroxyvitamin D3, parathyroid hormone, overweight, triglycerides, TNF-α, LDL cholesterol, lipolysis, lipogenesis, inflammation
- MeSH
- adipose tissue, humans, cardiovascular diseases, obesity, inflammation, weight loss, calcifediol, vitamin d, tumor necrosis factor-alpha, placebos, risk factors, double-blind method, dietary supplements, adult, middle aged, female, male, overweight, biomarkers
9 autores
- Armin Zittermann🇩🇪 · autor de correspondenciaUniversity of Bonn; Charité - Universitätsmedizin Berlin; Ruhr University Bochum
- Sabine Frisch🇩🇪University of Bonn; Charité - Universitätsmedizin Berlin; Ruhr University Bochum
- Heiner K. Berthold🇩🇪University of Bonn; Charité - Universitätsmedizin Berlin; Ruhr University Bochum
- Christian Götting🇩🇪University of Bonn; Charité - Universitätsmedizin Berlin; Ruhr University Bochum
- Joachim Kühn🇩🇪University of Bonn; Charité - Universitätsmedizin Berlin; Ruhr University Bochum
- Knut Kleesiek🇩🇪University of Bonn; Charité - Universitätsmedizin Berlin; Ruhr University Bochum
- Peter Stehle🇩🇪University of Bonn; Charité - Universitätsmedizin Berlin; Ruhr University Bochum
- Heinrich Koertke🇩🇪University of Bonn; Charité - Universitätsmedizin Berlin; Ruhr University Bochum
- Reiner Köerfer🇩🇪University of Bonn; Charité - Universitätsmedizin Berlin; Ruhr University Bochum
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
High blood concentrations of parathyroid hormone and low concentrations of the vitamin D metabolites 25-hydroxyvitamin D [25(OH)D] and calcitriol are considered new cardiovascular disease risk markers. However, there is also evidence that calcitriol increases lipogenesis and decreases lipolysis.
Objective
We investigated the effect of vitamin D on weight loss and traditional and nontraditional cardiovascular disease risk markers in overweight subjects.
Design
Healthy overweight subjects (n = 200) with mean 25(OH)D concentrations of 30 nmol/L (12 ng/mL) received vitamin D (83 microg/d) or placebo in a double-blind manner for 12 mo while participating in a weight-reduction program.
Results
Weight loss was not affected significantly by vitamin D supplementation (-5.7 +/- 5.8 kg) or placebo (-6.4 +/- 5.6 kg). However, mean 25(OH)D and calcitriol concentrations increased by 55.5 nmol/L and 40.0 pmol/L, respectively, in the vitamin D group but by only 11.8 nmol/L and 9.3 pmol/L, respectively, in the placebo group (P < 0.001), whereas a more pronounced decrease occurred in the vitamin D group than in the placebo group in blood concentrations of parathyroid hormone (-26.5% compared with -18.7%; P = 0.014), triglycerides (-13.5% compared with +3.0%; P < 0.001), and the inflammation marker tumor necrosis factor-alpha (-10.2% compared with -3.2%; P = 0.049). The beneficial biochemical effects were independent of the loss in body weight, fat mass, and sex. However, compared with placebo, vitamin D supplementation also increased LDL-cholesterol concentrations (+5.4% compared with -2.5%; P < 0.001).
Conclusions
The results indicate that a vitamin D supplement of 83 microg/d does not adversely affect weight loss and is able to significantly improve several cardiovascular disease risk markers in overweight subjects with inadequate vitamin D status participating in a weight-reduction program. This trial was registered at clinicaltrials.gov as NCT00493012.
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