Effects of caffeine on daytime recovery sleep: A double challenge to the sleep-wake cycle in aging
Carrier J, Paquet J, Fernandez-Bolanos M, Girouard L, Roy J, Selmaoui B, Filipini D
Sleep medicine · 52 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Canadian Institutes of Health Research
- Gobierno
- Natural Sciences and Engineering Research Council of Canada
- Gobierno
- Fonds de Recherche du Québec - Santé
Según 3 financiadores declarados.
Publicación
- Publicado
- 2009-04-02 · Sleep Med · vol. 10 · número 9 · págs. 1016–1024
- Editorial
- Elsevier BV
- Citado
- 82 citas · más que el 92% de estudios similares · 4.0× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 74 trabajos
- Acceso
- De pago
- Áreas de investigación
- Sleep and Work-Related Fatigue · Sleep and Wakefulness Research · Sleep and related disorders
- Palabras clave
- caffeine, aging, sleep efficiency, slow-wave sleep, REM sleep, circadian rhythm, sleep fragmentation, EEG synchronization, middle-aged adults, sleep duration, jet lag, night work
- MeSH
- humans, sleep deprivation, caffeine, central nervous system stimulants, polysomnography, cross-over studies, double-blind method, wakefulness, sleep, age factors, recovery of function, circadian rhythm, adult, middle aged, female, male, young adult
7 autores
- Julie Carrier🇨🇦Hôpital du Sacré-Cœur de Montréal; Université de Montréal
- Jean Paquet🇨🇦Hôpital du Sacré-Cœur de Montréal
- Marta Fernandez‐Bolaños🇨🇦Université de Montréal
- Laurence Girouard🇨🇦Université de Montréal
- Joanie Roy🇨🇦Université de Montréal
- Brahim Selmaoui🇨🇦Hôpital du Sacré-Cœur de Montréal
- Daniel Filipini🇨🇦Hôpital du Sacré-Cœur de Montréal
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background and objective
Caffeine is the most widely used stimulant to counteract the effects of sleepiness, but it also produces important detrimental effects on subsequent sleep, especially when sleep is initiated at a time when the biological clock sends a strong waking signal such as during daytime. This study compares the effects of caffeine on daytime recovery sleep in young (20-30 y.) and middle-aged subjects (45-60 y.).
Methods
Subjects participated in both caffeine (200mg) and placebo conditions (double-blind cross-over design), spaced one month apart. For each condition, subjects initially came to the laboratory for a nocturnal sleep episode. Daytime recovery sleep started in the morning after 25h of wakefulness. Subjects were administered either one caffeine (100mg) or placebo capsule three hours before daytime recovery sleep and the remaining dose one hour before daytime recovery sleep.
Results
Middle-aged subjects showed greater decrements of sleep duration and sleep efficiency than young subjects during daytime recovery under placebo compared to nocturnal sleep. Caffeine decreased sleep efficiency, sleep duration, slow-wave sleep (SWS) and REM sleep during daytime recovery sleep similarly in both age groups. Caffeine also reduced N-REM sleep EEG synchronization during daytime recovery sleep (reduced delta, theta, and alpha power, and greater beta power).
Conclusions
The combined influence of age and caffeine made the sleep of middle-aged subjects particularly vulnerable to the circadian waking signal. We propose that lower brain synchronization due to age and caffeine produces greater difficulty in overriding the circadian waking signal during daytime sleep and leads to fragmented sleep. These results have implications for the high proportion of the population using caffeine to cope with night work and jet lag, particularly the middle-aged.
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