Dietary sulforaphane-rich broccoli sprouts reduce colonization and attenuate gastritis in Helicobacter pylori-infected mice and humans
Yanaka A, Fahey JW, Fukumoto A, Nakayama M, Inoue S, Zhang S, Tauchi M, Suzuki H, Hyodo I, Yamamoto M
Cancer prevention research (Philadelphia, Pa.) · 179 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas, más trabajo en animales o laboratorio
- Resultado principal
- Marcadores de salud y funcionamiento
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Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2009-04-01 · Cancer Prev Res (Phila) · vol. 2 · número 4 · págs. 353–360
- Editorial
- American Association for Cancer Research
- Citado
- 276 citas · más que el 99% de estudios similares · 15.7× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 43 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Helicobacter pylori-related gastroenterology studies · Genomics, phytochemicals, and oxidative stress · Gut microbiota and health
- Palabras clave
- sulforaphane, broccoli sprouts, Helicobacter pylori infection, gastric colonization, gastritis, Nrf2, isothiocyanates, glucoraphanin, oxidative stress, serum pepsinogen, urea breath test, gastric cancer chemoprevention, high-salt diet
- MeSH
- feces, animals, mice, inbred c57bl, mice, knockout, humans, mice, helicobacter pylori, brassica, medicago sativa, helicobacter infections, gastritis, thiocyanates, isothiocyanates, sulfoxides, pepsinogen a, urease, anticarcinogenic agents, antigens, bacterial, phytotherapy, female, nf-e2-related factor 2
10 autores
- Akinori Yanaka🇺🇸🇯🇵 · autor de correspondenciaJohns Hopkins University; University of Tsukuba; Tokyo University of Science
- Jed W. Fahey🇺🇸🇯🇵Johns Hopkins University; University of Tsukuba; Tokyo University of Science
- Atsushi Fukumoto🇺🇸🇯🇵Johns Hopkins University; University of Tsukuba; Tokyo University of Science
- Mari Nakayama🇺🇸🇯🇵Johns Hopkins University; University of Tsukuba; Tokyo University of Science
- Souta Inoue🇺🇸🇯🇵Johns Hopkins University; University of Tsukuba; Tokyo University of Science
- Songhua Zhang🇺🇸🇯🇵Johns Hopkins University; University of Tsukuba; Tokyo University of Science
- Masafumi Tauchi🇺🇸🇯🇵Johns Hopkins University; University of Tsukuba; Tokyo University of Science
- Hideo Suzuki🇺🇸🇯🇵Johns Hopkins University; University of Tsukuba; Tokyo University of Science
- Ichinosuke Hyodo🇺🇸🇯🇵Johns Hopkins University; University of Tsukuba; Tokyo University of Science
- Masayuki P. Yamamoto🇺🇸🇯🇵Johns Hopkins University; University of Tsukuba; Tokyo University of Science
Resumen
El texto original del estudio, en el idioma en que se publicó.
The isothiocyanate sulforaphane [SF; 1-isothiocyanato-4(R)-methylsulfinylbutane] is abundant in broccoli sprouts in the form of its glucosinolate precursor (glucoraphanin). SF is powerfully bactericidal against Helicobacter pylori infections, which are strongly associated with the worldwide pandemic of gastric cancer. Oral treatment with SF-rich broccoli sprouts of C57BL/6 female mice infected with H. pylori Sydney strain 1 and maintained on a high-salt (7.5% NaCl) diet reduced gastric bacterial colonization, attenuated mucosal expression of tumor necrosis factor-alpha and interleukin-1beta, mitigated corpus inflammation, and prevented expression of high salt-induced gastric corpus atrophy. This therapeutic effect was not observed in mice in which the nrf2 gene was deleted, strongly implicating the important role of Nrf2-dependent antioxidant and anti-inflammatory proteins in SF-dependent protection. Forty-eight H. pylori-infected patients were randomly assigned to feeding of broccoli sprouts (70 g/d; containing 420 micromol of SF precursor) for 8 weeks or to consumption of an equal weight of alfalfa sprouts (not containing SF) as placebo. Intervention with broccoli sprouts, but not with placebo, decreased the levels of urease measured by the urea breath test and H. pylori stool antigen (both biomarkers of H. pylori colonization) and serum pepsinogens I and II (biomarkers of gastric inflammation). Values recovered to their original levels 2 months after treatment was discontinued. Daily intake of sulforaphane-rich broccoli sprouts for 2 months reduces H. pylori colonization in mice and improves the sequelae of infection in infected mice and in humans. This treatment seems to enhance chemoprotection of the gastric mucosa against H. pylori-induced oxidative stress.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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