Effects of oral magnesium supplementation on insulin sensitivity and blood pressure in normo-magnesemic nondiabetic overweight Korean adults
Lee S, Park HK, Son SP, Lee CW, Kim IJ, Kim HJ
Nutrition, metabolism, and cardiovascular diseases : NMCD · 39 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Pusan National University
Según 1 financiador declarado.
Publicación
- Publicado
- 2009-04-09 · Nutr Metab Cardiovasc Dis · vol. 19 · número 11 · págs. 781–788
- Editorial
- Elsevier BV
- Citado
- 56 citas · más que el 92% de estudios similares · 3.6× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 39 trabajos
- Acceso
- De pago
- Áreas de investigación
- Magnesium in Health and Disease · Magnesium Oxide Properties and Applications · Blood Pressure and Hypertension Studies
- Palabras clave
- magnesium supplementation, oral magnesium, insulin sensitivity, insulin resistance, blood pressure, hypertension, overweight adults, magnesium oxide, subgroup analysis, HOMA-IR
- MeSH
- humans, insulin resistance, magnesium oxide, insulin, blood glucose, lipids, administration, oral, double-blind method, blood pressure, time factors, dietary supplements, adult, middle aged, female, male, overweight, republic of korea, biomarkers, asian people
6 autores
- Sang Yeoup Lee🇰🇷Pusan National University Hospital; Pusan National University
- H.K. Park
- Say-Jin Son🇰🇷BongSeng Memorial Hospital
- Chang Won Lee
- I.J. Kim🇰🇷Pusan National University
- H.J. Kim🇰🇷Busan National University of Education; Pusan National University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background and aim
Little is known about the effect of magnesium on insulin sensitivity and BP in healthy individuals. Therefore, we investigated whether magnesium could improve insulin sensitivity and blood pressure (BP) in normo-magnesemic nondiabetic overweight adults.
Methods and results
In a double-blinded, placebo-controlled, randomized trial, a total of 155 participants (BMI > or = 23 kg/m(2)) received either 12.3 mmol (300 mg) of elemental magnesium in the form of magnesium oxide (n=75) or placebo (n=80) each day for 12 weeks, constituting the intent-to-treat population. A repeated-measures ANOVA was used to evaluate the between-group changes in variables during the study. The baseline characteristics between the intervention and control groups were similar. There were no significant differences between the groups in the pattern of change of the homeostasis model assessment insulin resistance index, BP over time during the 12-week study. In subgroup analysis, magnesium supplementation (n=8, 27, and 24, respectively) lowered BP much more than placebo (n=16, 29, and 25, respectively) in those subjects whose systolic BP > or = 140 mmHg, diastolic BP 80-90 mmHg, and diastolic BP > or = 90 mmHg at the start of the study (P=0.016, 0.043, and 0.023, respectively); in comparison, those subjects whose initial BP reading was low at baseline did not show a change in BP. No significant adverse events related to magnesium supplementation were recorded.
Conclusions
These results suggested that magnesium supplementation does not reduce BP and enhance insulin sensitivity in normo-magnesemic nondiabetic overweight people. However, it appears that magnesium supplementation may lower BP in healthy adults with higher BP.
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