Supplementation with cholecalciferol does not improve glycaemic control in diabetic subjects with normal serum 25-hydroxyvitamin D levels
Jorde R, Figenschau Y
European journal of nutrition · 173 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2009-04-15 · Eur J Nutr · vol. 48 · número 6 · págs. 349–354
- Editorial
- Springer Science+Business Media
- Citado
- 244 citas · más que el 99% de estudios similares · 14.9× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 30 trabajos
- Acceso
- De pago
- Áreas de investigación
- Vitamin D Research Studies · Diabetes Treatment and Management · Diabetes Management and Research
- Palabras clave
- vitamin D supplementation, vitamin D3, type 2 diabetes, glycemic control, 25-hydroxyvitamin D, insulin sensitivity, insulin secretion, metformin, HbA1c, fasting blood glucose, C-peptide, fructosamine
- MeSH
- humans, diabetes mellitus, type 2, calcium, metformin, cholecalciferol, calcifediol, insulin, insulin, long-acting, c-peptide, fructosamine, blood glucose, dietary supplements, adult, aged, middle aged, female, male, young adult, glycated hemoglobin
2 autores
- Rolf Jorde🇳🇴 · autor de correspondenciaUiT The Arctic University of Norway
- Yngve Figenschau🇳🇴University Hospital of North Norway; UiT The Arctic University of Norway
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Studies have suggested that vitamin D may be important for both insulin sensitivity and insulin secretion, and that supplementation with vitamin D may subsequently prevent development of type 2 diabetes.
Aim of the study
The objective of the current study was to test the hypothesis that supplementation with vitamin D would improve glycaemic control in subjects with type 2 diabetes.
Methods
Thirty-six subjects with type 2 diabetes, treated with metformin and bed-time insulin, were randomised to supplementation with cholecalciferol (40,000 IU per week) versus placebo for 6 months. Thirty-two subjects participated throughout the entirety of the study. Fasting blood samples were drawn before and at the end of the 6 month study without the previous bed-time insulin injection. The insulin and metformin doses were not changed throughout the study.
Results
After 6 months, the fasting glucose, insulin, C-peptide, fructosamine, and HbA(1c) levels were not significantly different from baseline values. In addition, changes in these parameters (values at 6 months minus values at baseline) did not differ between the vitamin D and the placebo group.
Conclusions
We were not able to demonstrate that vitamin D supplementation had a significant effect on glucose metabolism in subjects with type 2 diabetes but without vitamin D deficiency. Further studies are needed in larger groups of subjects with type 2 diabetes or impaired glucose tolerance, who also exhibit low serum 25-hydroxyvitamin D levels.
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