Omega 3 and 6 oils for primary prevention of allergic disease: systematic review and meta-analysis
Anandan C, Nurmatov U, Sheikh A
Allergy · 88 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Chief Scientist Office
Según 1 financiador declarado.
Publicación
- Publicado
- 2009-04-07 · Allergy · vol. 64 · número 6 · págs. 840–848
- Editorial
- Wiley
- Citado
- 145 citas · más que el 81% de estudios similares · 1.9× el promedio de su campo
- Referencias
- 29 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Fatty Acid Research and Health · Asthma and respiratory diseases · Food Allergy and Anaphylaxis Research
- Palabras clave
- omega-3 fatty acids, omega-6 fatty acids, dietary supplementation, allergy prevention, allergen sensitization, atopic dermatitis, asthma, allergic rhinitis, food allergy, primary prevention
- MeSH
- animals, humans, asthma, dermatitis, atopic, eczema, hypersensitivity, food hypersensitivity, fatty acids, omega-3, fatty acids, omega-6, dietary supplements, rhinitis, allergic, seasonal
3 autores
- Chantelle Anandan🇬🇧University of Edinburgh
- Ulugbek B. Nurmatov🇬🇧University of Edinburgh
- Aziz Sheikh🇬🇧 · autor de correspondenciaUniversity of Edinburgh
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
There is conflicting evidence on the use of omega 3 and omega 6 supplementation for the prevention of allergic diseases. We conducted a systematic review evaluating the effectiveness of omega 3 and 6 oils for the primary prevention of sensitization and development of allergic disorders.
Methods
We searched The Cochrane Central Register of Controlled Trials, MEDLINE, EMBASE, LILACS, PsycInfo, AMED, ISI Web of Science and Google Scholar for double-blind randomized controlled trials. Two authors independently assessed articles for inclusion. Meta-analyses were undertaken using fixed effects modelling, or random effects modelling in the event of detecting significant heterogeneity.
Results
Of the 3129 articles identified, 10 reports (representing six unique studies) satisfied the inclusion criteria. Four studies compared omega 3 supplements with placebo and two studies compared omega 6 supplements with placebo. There was no clear evidence of benefit in relation to reduced risk of allergic sensitization or a favourable immunological profile. Meta-analyses failed to identify any consistent or clear benefits associated with use of omega 3 [atopic eczema: RR = 1.10 (95% CI 0.78-1.54); asthma: RR = 0.81 (95% CI 0.53-1.25); allergic rhinitis: RR = 0.80 (95% CI 0.34-1.89) or food allergy RR = 0.51 (95% CI 0.10-2.55)] or omega 6 oils [atopic eczema: RR = 0.80 (95% CI 0.56-1.16)] for the prevention of clinical disease.
Conclusions
Contrary to the evidence from basic science and epidemiological studies, our systematic review and meta-analysis suggests that supplementation with omega 3 and omega 6 oils is probably unlikely to play an important role as a strategy for the primary prevention of sensitization or allergic disease.
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