Fish oil supplementation improves endothelial function in normoglycemic offspring of patients with type 2 diabetes
Rizza S, Tesauro M, Cardillo C, Galli A, Iantorno M, Gigli F, Sbraccia P, Federici M, Quon MJ, Quon MJ, Lauro D
Atherosclerosis · 89 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Institutes of Health
- Gobierno
- Intramural NIH HHS
- Subvenciones
- National Institutes of Health (Z01 AT000001)
Según 2 financiadores declarados.
Publicación
- Publicado
- 2009-03-20 · Atherosclerosis · vol. 206 · número 2 · págs. 569–574
- Editorial
- Elsevier BV
- Citado
- 117 citas · más que el 98% de estudios similares · 8.2× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 42 trabajos
- Acceso
- Acceso abierto (copia en repositorio)
- Áreas de investigación
- Fatty Acid Research and Health · Birth, Development, and Health · Nitric Oxide and Endothelin Effects
- Palabras clave
- fish oil supplementation, omega-3 fatty acids, endothelial dysfunction, flow-mediated dilation, TNF-α, adiponectin, insulin resistance, plasma triglycerides, inflammation, cardiovascular risk
- MeSH
- endothelium, humans, diabetes mellitus, type 2, genetic predisposition to disease, blood glucose, fatty acids, omega-3, fish oils, tumor necrosis factor-alpha, double-blind method, adult, female, male
10 autores
- Stefano Rizza🇮🇹 · autor de correspondenciaPoliclinico Tor Vergata
- Manfredi Tesauro🇮🇹Policlinico Tor Vergata
- Carmine Cardillo🇮🇹Università Cattolica del Sacro Cuore
- Angelica Galli🇮🇹Policlinico Tor Vergata
- Micaela Iantorno🇺🇸National Institutes of Health; National Center for Complementary and Integrative Health
- Fabrizio Gigli🇮🇹Policlinico Tor Vergata
- Paolo Sbraccia🇮🇹Policlinico Tor Vergata
- Massimo Federici🇮🇹Policlinico Tor Vergata
- Michael J. Quon🇺🇸National Institutes of Health; National Center for Complementary and Integrative Health
- Davide Lauro🇮🇹Policlinico Tor Vergata
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
Offspring of patients with type 2 diabetes (OPDs) exhibits endothelial dysfunction (ED) associated with a chronic inflammatory state. N-3 polyunsaturated fatty acids (n-3 PUFA) may have antioxidant and anti-inflammatory properties that are beneficial for cardiovascular and metabolic health. Therefore, in the present study, we tested the hypothesis that dietary supplementation with fish oil rich in n-3 PUFA may improve ED in otherwise healthy OPDs.
Methods and design
A double-blind, placebo-controlled trial was conducted with 50 OPDs. Participants were randomized to treatment with either placebo or n-3 PUFA (2g/day) for 12 weeks. Before and after treatment we evaluated endothelial function (using flow-mediated dilation (FMD) of the brachial artery), circulating inflammatory markers (adiponectin, TNF-alpha, and high sensitivity-CRP), and insulin resistance (QUICKI).
Results
No significant changes were observed in study outcomes in subjects treated with placebo. By contrast, when compared with baseline values, subjects treated with n-3 PUFA had significant improvement in FMD (9.1+/-5.8% vs. 11.7+/-4.4%, p=0.02) that was accompanied by decreased plasma triglycerides (117+/-73mg/dl vs. 86+/-44mg/dl, p=0.001) and TNF-alpha levels (8.9+/-2.3pg/ml vs. 6.8+/-2.7pg/ml, p=0.001), and a trend towards increased plasma adiponectin levels (7.8+/-4.5microg/ml vs. 9.5+/-5.1microg/ml, p=0.09). When data were analyzed by multiple regression analysis, decreased TNF-alpha after treatment with n-3 PUFA predicted increased FMD.
Conclusion
Dietary supplementation with n-3 PUFA significantly improved endothelial function and reduced pro-inflammatory markers in OPDs. Thus, fish oil consumption may have beneficial cardiovascular and metabolic health effects in otherwise healthy subjects predisposed to diabetes and its vascular complications.
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