Existing and potentially novel functional markers of vitamin D status: a systematic review
Seamans KM, Cashman KD
The American journal of clinical nutrition · 188 citas
Etiquetas de revisión
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Cómo se estudió
- Diseño
- Revisión sistemática (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2009-04-30 · Am J Clin Nutr · vol. 89 · número 6 · págs. 1997S–2008S
- Editorial
- Elsevier BV
- Citado
- 268 citas · más que el 87% de estudios similares · 2.0× el promedio de su campo
- Referencias
- 77 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Vitamin D Research Studies · Bone health and osteoporosis research · Parathyroid Disorders and Treatments
- Palabras clave
- vitamin D status, 25-hydroxyvitamin D, parathyroid hormone, bone turnover markers, bone mineral density, intestinal calcium absorption, vitamin D supplementation, calcium supplementation, biomarkers, older adults, adolescents
- MeSH
- humans, calcium, parathyroid hormone, vitamins, vitamin d, nutrition assessment, methods, nutritional status, intestinal absorption, bone density, dietary supplements, biomarkers
2 autores
- Kelly M. Seamans🇮🇪University College Cork
- Kevin D. Cashman🇮🇪 · autor de correspondenciaUniversity College Cork
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Although serum 25-hydroxyvitamin D [25(OH)D] is the currently accepted vitamin D status marker of choice, use of other biomarkers or functional endpoints have been suggested.
Objective
The objective was to systematically review the effectiveness of 25(OH)D, parathyroid hormone (PTH), bone turnover markers, bone mineral density (BMD), and calcium absorption as biomarkers of vitamin D status.
Design
Methods included a structured search on Ovid MEDLINE, EMBASE (Ovid), and Cochrane CENTRAL; rigorous inclusion/exclusion criteria; data extraction; quality assessment; meta-analysis; and meta-regression.
Results
Thirty-six vitamin D supplementation randomized controlled trials (RCTs) and 4 before-after studies were included. Vitamin D supplementation significantly raised circulating 25(OH)D in all but one RCT, but the response was highly heterogeneous [weighted mean difference (WMD): 34.1 nmol/L; 95% CI: 28.9, 39.2; 32 RCTs; I2 = 97%). Vitamin D supplementation (without calcium) significantly lowered circulating PTH (WMD: -0.29 pmol/L; 95% CI: -0.56, -0.02; 11 RCTs; I2 = 29%), but this was not apparent in the presence of calcium supplementation. There was a suggestion that whole-body or lumbar spine BMD may be a useful biomarker in older people but not in adolescents. Bone turnover markers were not useful biomarkers of vitamin D status, but 4 before-after studies suggested that intestinal calcium absorption may respond to vitamin D status.
Conclusions
This systematic review confirmed that circulating 25(OH)D is a robust and reliable marker of vitamin D status. Further research is needed to clarify which population subgroups show responses of PTH, BMD, and/or calcium absorption in response to changes in vitamin D status.
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