The effects of a low-sodium base-producing diet including red meat compared with a high-carbohydrate, low-fat diet on bone turnover markers in women aged 45-75 years
Nowson CA, Patchett A, Wattanapenpaiboon N
The British journal of nutrition · 20 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2009-05-18 · Br J Nutr · vol. 102 · número 8 · págs. 1161–1170
- Editorial
- Cambridge University Press
- Citado
- 31 citas · más que el 87% de estudios similares · 2.2× el promedio de su campo
- Referencias
- 46 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Bone health and osteoporosis research · Sodium Intake and Health · Nutritional Studies and Diet
- Palabras clave
- DASH diet, red meat, high-carbohydrate low-fat diet, bone turnover markers, bone resorption, urinary calcium excretion, urinary sodium, urinary potassium, acid load, prehypertension, hypertension, postmenopausal women, C-terminal telopeptide of type I collagen, 25-hydroxyvitamin D, parathyroid hormone, osteocalcin
- MeSH
- humans, bone resorption, hypertension, body weight, potassium, sodium, calcium, dietary carbohydrates, diet, fat-restricted, diet, sodium-restricted, diet, bone remodeling, acid-base equilibrium, blood pressure, meat, aged, middle aged, female, biomarkers
3 autores
- Caryl Anne Nowson🇦🇺 · autor de correspondenciaDeakin University
- A. Patchett🇦🇺Deakin University
- Naiyana Wattanapenpaiboon🇦🇺Deakin University
Resumen
El texto original del estudio, en el idioma en que se publicó.
A randomised, parallel-design dietary intervention study was conducted in women (aged 45-75 years) with prehypertension or stage 1 hypertension. The aim was to compare the effects on bone turnover of a low-Na base-producing (LNAB) Dietary Approaches to Stop Hypertension (DASH)-type diet (including six serves lean red meat/week) with a high-carbohydrate low-fat (HCLF) diet with a higher acid load (both >800 mg dietary Ca/d). Fasting serum bone markers (baseline and week 14) and 24 h urinary electrolyte excretion (baseline, weeks 4, 8, 12 and 14) were measured. After the intervention period, the LNAB group (n 46) had a fall of 26 (sem 6) % (P < 0.0001) in urinary Na, an increase in K excretion (6.8 (sem 3.6) mmol/d; P = 0.07) and, compared with the HCLF group (n 49), a greater reduction in urinary Ca excretion by 0.7 (sem 0.3) mmol/d. Serum 25-hydroxyvitamin D, intact parathyroid hormone and osteocalcin did not change, and both groups had a similar increase of 23 (sem 5) % (P < 0.0001) in C-terminal telopeptide of type I collagen. The HCLF group had an 11 (sem 4) % increase (P = 0.003) in N-terminal propeptide, type I procollagen, which could indicate an increased rate of bone turnover. The fall in urinary Ca with the lower-Na lower-acid load diet is likely to have long-term beneficial effects on bone. As bone resorption was not different between the two dietary patterns with relatively high Ca intake, the effect on bone health of a dietary pattern with a lower acid load warrants further study on a lower Ca intake.
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