Short-term oral magnesium supplementation suppresses bone turnover in postmenopausal osteoporotic women
Aydin H, Deyneli O, Yavuz D, Gözü H, Mutlu N, Kaygusuz I, Akalin S
Biological trace element research · 59 citas
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Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2009-06-01 · Biol Trace Elem Res · vol. 133 · número 2 · págs. 136–143
- Editorial
- Springer Science+Business Media
- Citado
- 93 citas · más que el 94% de estudios similares · 4.6× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 32 trabajos
- Acceso
- De pago
- Áreas de investigación
- Magnesium in Health and Disease · Bone health and osteoporosis research · Magnesium Alloys: Properties and Applications
- Palabras clave
- magnesium supplementation, magnesium citrate, bone turnover, postmenopausal osteoporosis, bone mineral density, parathyroid hormone, osteocalcin, deoxypyridinoline, urinary biomarkers, postmenopausal women
- MeSH
- bone and bones, animals, humans, rats, osteoporosis, postmenopausal, citric acid, organometallic compounds, parathyroid hormone, amino acids, osteocalcin, administration, oral, bone density, dietary supplements, middle aged, female, biomarkers
7 autores
- Hasan Aydın🇹🇷 · autor de correspondenciaYeditepe University Hospital
- Oğuzhan Deyneli🇹🇷Marmara University
- Dilek Gogaş Yavuz🇹🇷Marmara University
- Hülya Ilıksu Gözü🇹🇷Dr Lütfi Kırdar Kartal Eğitim ve Araştırma Hastanesi
- Nilgün Mutlu🇹🇷Yeditepe University Hospital
- Işık Kaygusuz🇹🇷Marmara University
- Sema Akalın🇹🇷Marmara University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Magnesium has been shown to increase bone mineral density when used in the treatment of osteoporosis, yet its mechanism of action is obscure. In this study, the effects of daily oral magnesium supplementation on biochemical markers of bone turnover were investigated. Twenty postmenopausal women have been divided into two groups. Ten patients were given magnesium citrate (1,830 mg/day) orally for 30 days. Ten postmenopausal women of matching age, menopause duration, and BMI were recruited as the control group and followed without any medication. Fasting blood and first-void urine samples were collected on days 0, 1, 5, 10, 20, and 30, respectively. Total magnesium, calcium, phosphorus, iPTH and osteocalcin were determined in blood samples. Deoxypyridinoline levels adjusted for creatinine were measured in urine samples. Thirty consecutive days of oral magnesium supplementation caused significantly decrease in serum iPTH levels in the Mg-supplemented group (p < 0.05). Serum osteocalcin levels were significantly increased (p < 0.001) and urinary deoxypyridinoline levels were decreased (p < 0.001) in the Mg-supplemented group. This study has demonstrated that oral magnesium supplementation in postmenopausal osteoporotic women suppresses bone turnover.
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