Vitamin D for treatment and prevention of infectious diseases: a systematic review of randomized controlled trials
Yamshchikov AV, Desai NS, Blumberg HM, Ziegler TR, Tangpricha V
Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists · 199 citas
Cómo se estudió
- Diseño
- Revisión sistemática (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Institutes of Health
- Gobierno
- National Institute of Diabetes and Digestive and Kidney Diseases
- Gobierno
- National Institute of Arthritis and Musculoskeletal and Skin Diseases
- Gobierno
- National Center for Research Resources
- Gobierno
- National Center for Advancing Translational Sciences
- Gobierno
- NIAMS NIH HHS
- Gobierno
- NCRR NIH HHS
- Gobierno
- NIDDK NIH HHS
- Gobierno
- NCATS NIH HHS
- Subvenciones
- National Center for Advancing Translational Sciences (UL1 TR000454); National Institute of Arthritis and Musculoskeletal and Skin Diseases (K23 AR054334); National Center for Research Resources (K24 RR023356); National Institute of Diabetes and Digestive and Kidney Diseases (T32DK007298)
Según 9 financiadores declarados.
Publicación
- Publicado
- 2009-06-02 · Endocr Pract · vol. 15 · número 5 · págs. 438–449
- Editorial
- Elsevier BV
- Citado
- 305 citas · más que el 92% de estudios similares · 2.6× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 62 trabajos
- Acceso
- Acceso abierto (copia en repositorio)
- Áreas de investigación
- Vitamin D Research Studies · Nutrition and Health Studies · Immune responses and vaccinations
- Palabras clave
- vitamin D, vitamin D supplementation, infectious diseases, adjunctive therapy, tuberculosis, influenza, viral upper respiratory tract infection, vitamin D deficiency, immune response to infection, adverse events, clinical trial design
- MeSH
- humans, communicable diseases, vitamin d deficiency, vitamin d, randomized controlled trials as topic
5 autores
- Alexandra V. Yamshchikov🇺🇸 · autor de correspondenciaEmory University
- Nirali S. Desai
- Henry M. Blumberg🇺🇸Emory University
- Thomas R. Ziegler🇺🇸Emory University
- Vin Tangpricha🇺🇸Emory University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
To review the existing human controlled intervention studies of vitamin D as adjunctive therapy in settings of infection and provide recommendations for design and implementation of future studies in this field on the basis of the evidence reviewed.
Methods
We conducted a systematic review of randomized controlled clinical trials that studied vitamin D for treatment or prevention of infectious diseases in humans. Studies from 1948 through 2009 were identified through search terms in PubMed and Ovid MEDLINE.
Results
Thirteen published controlled trials were identified by our search criteria. Ten trials were placebo controlled, and 9 of the 10 were conducted in a rigorous double-blind design. The selected clinical trials demonstrated substantial heterogeneity in baseline patient demographics, sample size, and vitamin D intervention strategies. Serious adverse events attributable to vitamin D supplementation were rare across all studies. On the basis of studies reviewed to date, the strongest evidence supports further research into adjunctive vitamin D therapy for tuberculosis, influenza, and viral upper respiratory tract illnesses. In the selected studies, certain aspects of study design are highlighted to help guide future clinical research in the field.
Conclusion
More rigorously designed clinical trials are needed for further evaluation of the relationship between vitamin D status and the immune response to infection as well as for delineation of necessary changes in clinical practice and medical care of patients with vitamin D deficiency in infectious disease settings.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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