Reduced ex vivo interleukin-6 production by dietary fish oil is not modified by linoleic acid intake in healthy men
Damsgaard CT, Lauritzen L, Calder PC, Kjaer TR, Frøkiaer H
The Journal of nutrition · 13 citas
Etiquetas de revisión
Alimentación controladaFinanciación no declaradaSolo mecanismosDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Solo mecanismos
- Consumo medido con
- Comida provista por los investigadores
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2009-06-04 · J Nutr · vol. 139 · número 7 · págs. 1410–1414
- Editorial
- Elsevier BV
- Citado
- 17 citas · más que el 86% de estudios similares · 1.9× el promedio de su campo
- Referencias
- 31 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Fatty Acid Research and Health · Edible Oils Quality and Analysis · Aquaculture Nutrition and Growth
- Palabras clave
- fish oil, linoleic acid, interleukin-6, eicosapentaenoic acid, omega-3 fatty acids, dietary fatty acids, anti-inflammatory activity, whole blood cytokine production, peripheral blood mononuclear cells, monocytes, lipopolysaccharide stimulation, olive oil, TNF-α, IL-10, interferon-gamma, healthy men
- MeSH
- leukocytes, mononuclear, monocytes, humans, inflammation, lipids, fatty acids, fatty acids, unsaturated, linoleic acid, fish oils, interleukin-6, cytokines, diet, adult, male, young adult
5 autores
- Camilla Trab Damsgaard🇩🇰University of Copenhagen
- Lotte Lauritzen🇩🇰 · autor de correspondenciaUniversity of Copenhagen
- Philip C. Calder🇬🇧University of Southampton
- Tanja Kjær🇩🇰Technical University of Denmark
- Hanne Frøkiær🇩🇰Technical University of Denmark
Resumen
El texto original del estudio, en el idioma en que se publicó.
Fish oil (FO) is considered antiinflammatory, but evidence regarding its effect on human cytokine production is conflicting. High linoleic acid (LA) intake may impair any effects of FO. The aim of this study was to investigate how FO combined with high or low LA intake affected ex vivo cytokine production from cultures of whole blood, peripheral blood mononuclear cells (PBMC), and monocytes in healthy men. The study was a double-blinded, controlled, 2 x 2 factorial 8-wk intervention. Sixty-four healthy men were randomized to 5 mL/d FO or olive oil (OO) provided in capsules and to spreads and oils with high or low LA content, resulting in LA intakes of 7 +/- 2% and 4 +/- 1% energy, respectively. We measured eicosapentaenoic acid (EPA) in PBMC and stimulated cytokine production in whole blood and PBMC 24-h cultures before and immediately after intervention and after an 8-wk wash-out period, and in monocyte cultures immediately after intervention. PBMC-EPA was markedly increased by FO (P < 0.001). LA intake did not modify the incorporation of FO and tended to have only a slight effect on PBMC-EPA by itself (P = 0.06). Lipopolysaccharide (LPS)-stimulated whole-blood interleukin (IL)-6 production immediately after intervention was lower with FO than OO (P = 0.02) but did not correlate with PBMC-EPA in the FO groups (r = -0.12; P = 0.53; n = 31). The LA intake did not modify IL-6 production or the effect of FO. Neither FO nor LA intake affected the production of tumor necrosis factor-alpha, IL-10, or interferon-gamma in any of the cultures. In conclusion, FO intake reduced IL-6 production from LPS-stimulated whole blood in healthy men compared with OO, but the effect was not modified by the LA intake.
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