Financiado en parte por Teva Pharmaceutical Industries
Olive oil-based intravenous lipid emulsion in pediatric patients undergoing bone marrow transplantation: a short-term prospective controlled trial
Hartman C, Ben-Artzi E, Berkowitz D, Elhasid R, Lajterer N, Postovski S, Hadad S, Shamir R
Clinical nutrition (Edinburgh, Scotland) · 15 citas
Etiquetas de revisión
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiado por la industria
- Empresa
- Teva Pharmaceutical Industries
Según 1 financiador declarado.
Publicación
- Publicado
- 2009-06-04 · Clin Nutr · vol. 28 · número 6 · págs. 631–635
- Editorial
- Elsevier BV
- Citado
- 21 citas · más que el 76% de estudios similares · 0.8× el promedio de su campo
- Referencias
- 36 trabajos
- Acceso
- De pago
- Áreas de investigación
- Clinical Nutrition and Gastroenterology · Central Venous Catheters and Hemodialysis · Fatty Acid Research and Health
- Palabras clave
- intravenous lipid emulsion, parenteral nutrition, pediatric bone marrow transplantation, medium-chain triglycerides, long-chain triglycerides, plasma fatty acid profile, vitamin E, lipid peroxidation, cholesterol, oleic acid, arachidonic acid, engraftment
- MeSH
- humans, thiobarbituric acid reactive substances, vitamin e, lipids, fat emulsions, intravenous, plant oils, liver function tests, parenteral nutrition, bone marrow transplantation, prospective studies, lipid peroxidation, adolescent, child, child, preschool, infant, olive oil
8 autores
- Corina Hartman🇮🇱 · autor de correspondenciaTel Aviv University; Schneider Children's Medical Center
- Elisheva Ben‐Artzi🇮🇱Bar-Ilan University; Kinneret College on the Sea of Galilee
- Drora Berkowitz🇮🇱Rambam Health Care Campus; Meyer Children's Hospital
- Ronit Elhasid🇮🇱Rambam Health Care Campus; Meyer Children's Hospital
- Noah Lajterer🇮🇱Rambam Health Care Campus; Meyer Children's Hospital
- Sergey Postovsky🇮🇱Rambam Health Care Campus; Meyer Children's Hospital
- Salim Hadad🇮🇱Rambam Health Care Campus
- Raanan Shamir🇮🇱Tel Aviv University; Schneider Children's Medical Center
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background & aims
Parenteral nutrition (PN) is an important component of the supportive care of children undergoing bone marrow transplantation (BMT). The study aimed to assess short-term safety and metabolic effects of an olive oil-based (OO) lipid emulsion compared with a MCT/LCT (M/L) emulsion in the clinical setting of pediatric BMT.
Methods
Twenty-eight pediatric BMT patients (age 1-18 years) expected to need PN support for at least 2 weeks, were prospectively enrolled and randomly assigned to receive either OO or M/L lipid emulsions within PN. Clinical and routine laboratory parameters, plasma fatty acids profile, vitamin E and peroxidation status were recorded at baseline and after 14 days of PN.
Results
No significant differences were found for hematological parameters, liver enzymes, vitamins, plasma peroxidation status, percentage and time to engraftment. Taking into consideration the baseline fatty acids levels, the OO group showed higher oleic acid (p=0.012), linoleic (p=0.012) and arachidonic acid (p=0.002) enrichment but similar eicosapentanoic and docosahexanoic acids levels compared to the M/L group at day 14. Cholesterol levels decreased significantly in the OO group after 14 days on PN (p=0.017).
Conclusions
OO lipid emulsion was well tolerated, maintained essential fatty acids and peroxidation status, and generated a favorable plasma lipid profile. In this study short-term use of OO intravenous lipid emulsions was safe in children who needed PN support during BMT.
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