Effect of vitamin D on blood pressure: a systematic review and meta-analysis
Witham MD, Nadir MA, Struthers AD
Journal of hypertension · 250 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Organización sin fines de lucro
- British Heart Foundation
Según 1 financiador declarado.
Publicación
- Publicado
- 2009-10-01 · J Hypertens · vol. 27 · número 10 · págs. 1948–1954
- Editorial
- Lippincott Williams & Wilkins
- Citado
- 400 citas · más que el 94% de estudios similares · 3.3× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 33 trabajos
- Acceso
- De pago
- Áreas de investigación
- Vitamin D Research Studies · Blood Pressure and Hypertension Studies · Nutrition and Health Studies
- Palabras clave
- vitamin D, blood pressure, hypertension, vitamin D supplementation, activated vitamin D, vitamin D2, vitamin D3, UV-B radiation, systolic blood pressure, diastolic blood pressure, normotensive subjects
- MeSH
- humans, hypertension, vitamin d deficiency, vitamins, vitamin d, blood pressure
3 autores
- Miles D. Witham🇬🇧 · autor de correspondenciaUniversity of Dundee; Ninewells Hospital
- M. Adnan Nadir🇬🇧University of Dundee; Ninewells Hospital
- Allan D. Struthers🇬🇧University of Dundee; Ninewells Hospital
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objectives
Vitamin D insufficiency has been linked to hypertension and cardiovascular events in observational studies. It is unclear whether vitamin D supplementation can reduce blood pressure, and, if so, by how much.
Methods
We performed a systematic review and meta-analysis to examine whether vitamin D reduces blood pressure. Databases including MEDLINE, EMBASE, the Cumulative Index to Nursing and Allied Health Literature and the Cochrane library were searched, supplemented by searches of grey literature, unpublished trials and references from included studies. Studies were assessed by two reviewers independently according to a prespecified protocol. Interventions included activated vitamin D, unactivated vitamin D2 and D3 and ultraviolet B radiation.
Results
Eleven randomized, controlled trials fulfilled the inclusion criteria. Studies were small and of variable methodological quality. Mean baseline blood pressure was more than 140/90 mmHg in eight studies. Meta-analysis of these eight studies showed a nonsignificant reduction in systolic blood pressure in the vitamin D group compared with placebo [-3.6 mmHg, 95% confidence interval (CI) -8.0 to 0.7]. A small, statistically significant reduction was seen in diastolic blood pressure (-3.1 mmHg, 95% CI -5.5 to -0.6). Subgroup analysis suggested that unactivated vitamin D produced a greater fall in systolic blood pressure than activated vitamin D (-6.2 mmHg, 95% CI -12.32 to -0.04, vs. +0.7 mmHg, 95% CI -4.8 to 6.2). No reduction in blood pressure was seen in studies examining patients who were normotensive at baseline.
Conclusion
We found weak evidence to support a small effect of vitamin D on blood pressure in studies of hypertensive patients.
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