Omega-3 fatty acid supplements improve the cardiovascular risk profile of subjects with metabolic syndrome, including markers of inflammation and auto-immunity
Ebrahimi M, Ghayour-Mobarhan M, Rezaiean S, Hoseini M, Parizade SM, Farhoudi F, Hosseininezhad SJ, Tavallaei S, Vejdani A, Azimi-Nezhad M, Shakeri MT, Rad MA, Mobarra N, Kazemi-Bajestani SM, Ferns GA
Acta cardiologica · 77 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2009-06-17 · Acta Cardiol · vol. 64 · número 3 · págs. 321–327
- Editorial
- Taylor & Francis
- Citado
- 128 citas · más que el 94% de estudios similares · 4.6× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 39 trabajos
- Acceso
- De pago
- Áreas de investigación
- Fatty Acid Research and Health · Nutritional Studies and Diet · Edible Oils Quality and Analysis
- Palabras clave
- omega-3 fatty acids, fish oil supplementation, metabolic syndrome, cardiovascular risk, inflammation, autoimmunity, eicosapentaenoic acid, docosahexaenoic acid, C-reactive protein, lipid profile, blood pressure, body weight, LDL cholesterol, triglycerides
- MeSH
- humans, cardiovascular diseases, autoimmune diseases, inflammation, weight loss, fatty acids, omega-3, docosahexaenoic acids, eicosapentaenoic acid, fish oils, c-reactive protein, body mass index, risk factors, blood pressure, dietary supplements, adult, aged, middle aged, female, male, hsp27 heat-shock proteins, biomarkers, metabolic syndrome
15 autores
- Mahmoud Ebrahimi🇮🇷Mashhad University of Medical Sciences
- M. Ghayour- Mobarhan
- Shahab Rezaiean
- M. Hoseini🇮🇷Mashhad University of Medical Sciences
- S.M.R. Parizade
- Fateme Farhoudi
- S.J. Hosseininezhad
- Shima Tavallaei
- A. Vejdani🇮🇷Mashhad University of Medical Sciences
- Mohsen Azimi–Nezhad
- Mohammad Taghi Shakeri
- Mina AkbariRad
- Naser Mobarra
- Seyyed Mohammad Reza Kazemi‐Bajestani
- Gordon A. Ferns
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
Fish-oil contains high concentrations of omega-3 fatty acids that have been shown to have anti-inflammatory properties. We have evaluated the effects of purified omega-3 fatty acid supplements on several anthropometric and biochemical parameters, including heat shock protein (Hsp) 27 antibody titres in subjects with metabolic syndrome.
Methods
Subjects (n = 120) with metabolic syndrome (mean age of 52.9 +/- 11.9 years) were randomly allocated to one of two groups: sixty subjects were given 1 gram of fish oil as a single capsule, containing 180 mg eicosapentaenoic acid and 120 mg docosahexaenoic acid daily for 6 months. Control subjects did not receive any supplementation over the same period.
Results
The study was completed by 47 subjects in the intervention group and 42 subjects in the control group. Treatment with omega 3 supplements was associated with a significant fall in body weight (P < 0.05), systolic blood pressures (P < 0.05), serum low density lipoprotein cholesterol (P < 0.05), and total cholesterol (P < 0.05), triglycerides (P < 0.05), high-sensitivity C-reactive protein (hs-CRP) (P < 0.01), and Hsp27 antibody titres (P < 0.05). No significant changes were observed in the control group.
Conclusion
It appears that omega 3 improves the cardiovascular risk profile of subjects with metabolic syndrome, having effects on weight, systolic blood pressure, lipid profile and markers of inflammation and autoimmunity.
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