Vitamin D receptor gene polymorphisms, serum 25-hydroxyvitamin D levels, and melanoma: UK case-control comparisons and a meta-analysis of published VDR data
Randerson-Moor JA, Taylor JC, Elliott F, Chang YM, Beswick S, Kukalizch K, Affleck P, Leake S, Haynes S, Karpavicius B, Marsden J, Gerry E, Bale L, Bertram C, Field H, Barth JH, Silva Idos S, Swerdlow A, Kanetsky PA, Barrett JH, Bishop DT, Bishop JA
European journal of cancer (Oxford, England : 1990) · 107 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
- Organización sin fines de lucro
- Cancer Research UK
- Gobierno
- National Institute for Health and Care Research
- Gobierno
- National Cancer Institute
- Gobierno
- NCI NIH HHS
- Gobierno
- National Institute for Health Research (NIHR)
- Subvenciones
- National Cancer Institute (R01 CA83115); Cancer Research UK (A4994); Cancer Research UK (10589); National Cancer Institute (R01CA083115); Cancer Research UK (A6129)
Según 5 financiadores declarados.
Publicación
- Publicado
- 2009-07-18 · Eur J Cancer · vol. 45 · número 18 · págs. 3271–3281
- Editorial
- Elsevier BV
- Citado
- 147 citas · más que el 76% de estudios similares · 1.3× el promedio de su campo
- Referencias
- 61 trabajos
- Acceso
- Acceso abierto (revista híbrida) · OTHER-OA
- Áreas de investigación
- Vitamin D Research Studies · melanin and skin pigmentation · Cutaneous Melanoma Detection and Management
- Palabras clave
- vitamin D receptor, VDR polymorphisms, melanoma susceptibility, single nucleotide polymorphisms, serum 25-hydroxyvitamin D, body mass index, Breslow thickness, disease progression, genetic susceptibility
- MeSH
- humans, melanoma, obesity, genetic predisposition to disease, deoxyribonucleases, type ii site-specific, vitamin d, homeodomain proteins, receptors, calcitriol, body mass index, specimen handling, case-control studies, polymerase chain reaction, hair color, gene frequency, polymorphism, single nucleotide, alleles, adolescent, adult, aged, middle aged, female, male, gata transcription factors, statistics as topic, young adult, united kingdom, cdx2 transcription factor
22 autores
- Juliette A. Randerson‐Moor🇬🇧University of Leeds
- John Taylor🇬🇧University of Leeds
- Faye Elliott🇬🇧University of Leeds
- Yu‐Mei Chang🇬🇧University of Leeds
- Samantha Beswick🇬🇧University of Leeds
- Kairen Kukalizch🇬🇧University of Leeds
- Paul Affleck🇬🇧University of Leeds
- Susan Leake🇬🇧University of Leeds
- Sue Haynes🇬🇧University of Leeds
- Birute Karpavicius🇬🇧University of Leeds
- Jerry Marsden🇬🇧University of Leeds
- Edwina Gerry🇬🇧University of Leeds
- Linda Bale🇬🇧University of Leeds
- Chandra Gooptu Bertram🇬🇧University of Leeds
- Helen P. Field🇬🇧Leeds Teaching Hospitals NHS Trust
- Julian H. Barth🇬🇧Leeds Teaching Hospitals NHS Trust
- Isabel dos‐Santos‐Silva🇬🇧Cancer Research UK; London School of Hygiene & Tropical Medicine
- Anthony J. Swerdlow🇬🇧Institute of Cancer Research
- Peter A. Kanetsky🇺🇸University of Pennsylvania
- Jennifer H. Barrett🇬🇧University of Leeds
- David Timothy Bishop🇬🇧University of Leeds
- Julia Newton‐Bishop🇬🇧 · autor de correspondenciaUniversity of Leeds
Resumen
El texto original del estudio, en el idioma en que se publicó.
We have carried out melanoma case-control comparisons for six vitamin D receptor (VDR) gene single nucleotide polymorphisms (SNPs) and serum 25-hydroxyvitamin D(3) levels in order to investigate the role of vitamin D in melanoma susceptibility. There was no significant evidence of an association between any VDR SNP and risk in 1028 population-ascertained cases and 402 controls from Leeds, UK. In a second Leeds case-control study (299 cases and 560 controls) the FokI T allele was associated with increased melanoma risk (odds ratio (OR) 1.42, 95% confidence interval (CI) 1.06-1.91, p=0.02). In a meta-analysis in conjunction with published data from other smaller data sets (total 3769 cases and 3636 controls), the FokI T allele was associated with increased melanoma risk (OR 1.19, 95% CI 1.05-1.35), and the BsmI A allele was associated with a reduced risk (OR 0.81, 95% CI 0.72-0.92), in each instance under a parsimonious dominant model. In the first Leeds case-control comparison cases were more likely to have a higher body mass index (BMI) than controls (p=0.007 for linear trend). There was no evidence of a case-control difference in serum 25-hydroxyvitamin D(3) levels. In 1043 incident cases from the first Leeds case-control study, a single estimation of serum 25-hydroxyvitamin D(3) level taken at recruitment was inversely correlated with Breslow thickness (p=0.03 for linear trend). These data provide evidence to support the view that vitamin D and VDR may have a small but potentially important role in melanoma susceptibility, and putatively a greater role in disease progression.
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