Parenteral lipid emulsions based on olive oil compared with soybean oil in preterm (<28 weeks' gestation) neonates: a randomised controlled trial
Deshpande GC, Simmer K, Mori T, Croft K
Journal of pediatric gastroenterology and nutrition · 37 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2009-10-16 · J Pediatr Gastroenterol Nutr · vol. 49 · número 5 · págs. 619–625
- Editorial
- Lippincott Williams & Wilkins
- Citado
- 54 citas · más que el 93% de estudios similares · 4.1× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 27 trabajos
- Acceso
- De pago
- Áreas de investigación
- Clinical Nutrition and Gastroenterology · Fatty Acid Research and Health · Infant Nutrition and Health
- Palabras clave
- preterm infants, parenteral nutrition, polyunsaturated fatty acids, lipid peroxidation, F2-isoprostanes, vitamin E, oleic acid, linoleic acid, oxidative stress, red blood cell fatty acids, plasma fatty acids
- MeSH
- humans, fatty acids, omega-3, soybean oil, fat emulsions, intravenous, fatty acids, f2-isoprostanes, linoleic acid, oleic acid, plant oils, infusions, parenteral, double-blind method, lipid peroxidation, infant, newborn, infant, premature, australia, linoleoyl-coa desaturase, infant nutritional physiological phenomena, olive oil
4 autores
- Girish C. Deshpande🇦🇺 · autor de correspondenciaKing Edward Memorial Hospital
- Karen Norrie Simmer🇦🇺 · autor de correspondenciaKing Edward Memorial Hospital
- Trevor Anthony Mori🇦🇺The University of Western Australia
- Kevin D. Croft🇦🇺The University of Western Australia
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
: New olive oil-based (OL) lipid emulsions (olive:soy oil = 4:1) have lower polyunsaturated fatty acid (PUFA) (20% vs 60%) and higher vitamin E content (an antioxidant) compared with traditional soybean oil (SO) emulsions.
Objective
: Compare efficacy and safety of OL with SO emulsions in preterm neonates (<28 weeks) at high risk for oxidative stress.
Patients and methods
: Preterm neonates (gestation 23-<28 weeks) were randomised to receive OL or SO emulsion for 5 days using a standard protocol in a tertiary perinatal centre (King Edward Memorial Hospital for Women, Perth, Western Australia). Investigators and outcome assessors were masked to allocation. Plasma F2-isoprostanes (lipid peroxidation marker), plasma, and red blood cell fatty acids were measured before and after the study. Safety was monitored by liver function tests.
Results
: Forty-four of 50 participants (OL-23, SO-21) completed the study. Both emulsions were well tolerated with no significant adverse events. F2-isoprostane levels were comparable at baseline and study end. Oleic and linoleic acid levels were significantly high on day 6 in OL and SO groups, respectively. Long-chain PUFA levels were similar between groups despite the lower PUFA content of OL. The olive oil-based group had significantly higher levels of C18:4n-3, suggesting Delta6-desaturase enzyme inhibition in the SO group.
Conclusions
: Olive oil-based emulsion was safe and well tolerated by preterm neonates. Similar long-chain PUFA levels were achieved in the OL group despite significantly lower amount of PUFA content; however, there was no difference in lipid peroxidation (F2-isoprostane levels). Large trials are needed to confirm these benefits.
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