The effect of L-arginine and creatine on vascular function and homocysteine metabolism
Jahangir E, Vita JA, Handy D, Holbrook M, Palmisano J, Beal R, Loscalzo J, Eberhardt RT
Vascular medicine (London, England) · 48 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Institutes of Health
- Gobierno
- National Heart, Lung, and Blood Institute
- Gobierno
- NHLBI NIH HHS
- Subvenciones
- National Heart, Lung, and Blood Institute (R01 HL083269); National Heart, Lung, and Blood Institute (HL 55993); National Heart, Lung, and Blood Institute (P50HL083801); National Heart, Lung, and Blood Institute (R01 HL075795); National Heart, Lung, and Blood Institute (HL083269); National Heart, Lung, and Blood Institute (P01HL081587); National Heart, Lung, and Blood Institute (HL15157-31); National Heart, Lung, and Blood Institute (K12HL083781); National Heart, Lung, and Blood Institute (HL75795); National Heart, Lung, and Blood Institute (HL083781); National Heart, Lung, and Blood Institute (P01 HL060886); National Heart, Lung, and Blood Institute (P50HL055993); National Heart, Lung, and Blood Institute (HL-60886)
Según 3 financiadores declarados.
Publicación
- Publicado
- 2009-08-01 · Vasc Med · vol. 14 · número 3 · págs. 239–248
- Editorial
- SAGE Publishing
- Citado
- 72 citas · más que el 88% de estudios similares · 2.4× el promedio de su campo
- Referencias
- 53 trabajos
- Acceso
- Acceso abierto (copia en repositorio)
- Áreas de investigación
- Nitric Oxide and Endothelin Effects · Folate and B Vitamins Research · Cardiovascular Health and Disease Prevention
- Palabras clave
- arginine supplementation, creatine supplementation, homocysteine metabolism, endothelial function, flow-mediated dilation, guanidinoacetic acid, methionine metabolism, coronary artery disease, dietary supplements, nitric oxide
- MeSH
- brachial artery, humans, hyperemia, creatine, arginine, methionine, homocysteine, glycine, ultrasonography, treatment outcome, regional blood flow, vasodilation, dietary supplements, aged, middle aged, female, male, coronary artery disease
8 autores
- Eiman Jahangir🇺🇸Boston University
- Joseph A. Vita🇺🇸Boston University
- Diane E. Handy🇺🇸Harvard University
- Monica Holbrook🇺🇸Boston University
- Joseph N. Palmisano🇺🇸Boston University
- Ryan Beal🇺🇸Boston University
- Joseph Loscalzo🇺🇸Harvard University
- Robert T. Eberhardt🇺🇸 · autor de correspondenciaBoston University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Studies with L-arginine supplementation have shown inconsistent effects on endothelial function. The generation of guanidinoacetate (GAA) from L-arginine with subsequent formation of creatine and homocysteine and consumption of methionine may reduce the pool of L-arginine available for nitric oxide generation. Experimental studies suggest that creatine supplementation might block this pathway. We sought to determine the effects of L-arginine, creatine, or the combination on endothelium-dependent vasodilation and homocysteine metabolism in patients with coronary artery disease. Patients with coronary artery disease were randomized to L-arginine (9 g/day), creatine (21 g/day), L-arginine plus creatine, or placebo for 4 days (n = 26-29/group). Brachial artery flow-mediated dilation and plasma levels of L-arginine, creatine, homocysteine, methionine, and GAA were measured at baseline and follow-up. L-arginine and creatine supplementation had no effects on vascular function. L-arginine alone increased GAA (p < 0.01) and the ratio of homocysteine to methionine (p < 0.01), suggesting increased methylation demand. The combination of creatinine and L-arginine did not suppress GAA production or prevent the increase in homocysteine-to-methionine ratio. Unexpectedly, creatine supplementation (alone or in combination with L-arginine) was associated with an 11-20% increase in homocysteine concentration (p < 0.05), which was not attributable to worsened renal function, providing evidence against an effect of creatine on decreasing methylation demand. In conclusion, the present study provides no evidence that L-arginine supplementation improves endothelial function and suggests that l-arginine may increase methylation demand. Creatine supplementation failed to alter the actions of L-arginine on vascular function or suppress methylation demand. The unexpected increase in homocysteine levels following creatine supplementation could have adverse effects and merits further study, since creatine is a commonly used dietary supplement.
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