Dietary nitrate supplementation reduces the O2 cost of low-intensity exercise and enhances tolerance to high-intensity exercise in humans
Bailey SJ, Winyard P, Vanhatalo A, Blackwell JR, Dimenna FJ, Wilkerson DP, Tarr J, Benjamin N, Jones AM
Journal of applied physiology (Bethesda, Md. : 1985) · 566 citas
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- Ensayo controlado aleatorizado (indexado por PubMed)
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- Financiación no declarada
Publicación
- Publicado
- 2009-08-06 · J Appl Physiol (1985) · vol. 107 · número 4 · págs. 1144–1155
- Editorial
- American Physiological Society
- Citado
- 753 citas · más que el 100% de estudios similares · 84.3× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 69 trabajos
- Acceso
- De pago
- Áreas de investigación
- Cardiovascular and exercise physiology · Exercise and Physiological Responses · Muscle metabolism and nutrition
- Palabras clave
- nitrate supplementation, beetroot juice, inorganic nitrate, submaximal exercise, plasma nitrite, muscle oxygen extraction, time to exhaustion, systolic blood pressure, mitochondrial respiration
- MeSH
- muscle, skeletal, humans, beta vulgaris, plant roots, nitrites, hemoglobins, oxyhemoglobins, plant preparations, spectroscopy, near-infrared, exercise, administration, oral, cross-over studies, double-blind method, oxygen consumption, blood pressure, muscle fatigue, exercise tolerance, muscle contraction, time factors, bicycling, beverages, dietary supplements, adult, male, young adult
9 autores
- Stephen J. Bailey🇬🇧University of Exeter
- Paul Graham Winyard🇬🇧University of Exeter; Peninsula College of Medicine and Dentistry
- Anni Vanhatalo
- Jamie R. Blackwell
- Fred J. DiMenna
- Daryl P. Wilkerson
- Joanna M. Tarr🇬🇧University of Exeter; Peninsula College of Medicine and Dentistry
- Nigel Benjamin🇬🇧University of Exeter; Peninsula College of Medicine and Dentistry
- ANDREW MARK JONES · autor de correspondencia
Resumen
El texto original del estudio, en el idioma en que se publicó.
Pharmacological sodium nitrate supplementation has been reported to reduce the O2 cost of submaximal exercise in humans. In this study, we hypothesized that dietary supplementation with inorganic nitrate in the form of beetroot juice (BR) would reduce the O2 cost of submaximal exercise and enhance the tolerance to high-intensity exercise. In a double-blind, placebo (PL)-controlled, crossover study, eight men (aged 19-38 yr) consumed 500 ml/day of either BR (containing 11.2 +/- 0.6 mM of nitrate) or blackcurrant cordial (as a PL, with negligible nitrate content) for 6 consecutive days and completed a series of "step" moderate-intensity and severe-intensity exercise tests on the last 3 days. On days 4-6, plasma nitrite concentration was significantly greater following dietary nitrate supplementation compared with PL (BR: 273 +/- 44 vs. PL: 140 +/- 50 nM; P < 0.05), and systolic blood pressure was significantly reduced (BR: 124 +/- 2 vs. PL: 132 +/- 5 mmHg; P < 0.01). During moderate exercise, nitrate supplementation reduced muscle fractional O2 extraction (as estimated using near-infrared spectroscopy). The gain of the increase in pulmonary O2 uptake following the onset of moderate exercise was reduced by 19% in the BR condition (BR: 8.6 +/- 0.7 vs. PL: 10.8 +/- 1.6 ml.min(-1).W(-1); P < 0.05). During severe exercise, the O2 uptake slow component was reduced (BR: 0.57 +/- 0.20 vs. PL: 0.74 +/- 0.24 l/min; P < 0.05), and the time-to-exhaustion was extended (BR: 675 +/- 203 vs. PL: 583 +/- 145 s; P < 0.05). The reduced O2 cost of exercise following increased dietary nitrate intake has important implications for our understanding of the factors that regulate mitochondrial respiration and muscle contractile energetics in humans.
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