Effect of eicosapentaenoic and docosahexaenoic acid on resting and exercise-induced inflammatory and oxidative stress biomarkers: a randomized, placebo controlled, cross-over study
Bloomer RJ, Larson DE, Fisher-Wellman KH, Galpin AJ, Schilling BK
Lipids in health and disease · 83 citas
Etiquetas de revisión
Financiado por la industriaSolo mecanismosDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Solo mecanismos
Quién lo pagó
- Financiación
- Financiado por la industria
- Universidad u hospital
- University of Memphis
Según 1 financiador declarado y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2009-01-01 · Lipids Health Dis · vol. 8 · número 1 · pág. 36
- Editorial
- BioMed Central
- Citado
- 150 citas · más que el 99% de estudios similares · 10.0× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 42 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Exercise and Physiological Responses · Fatty Acid Research and Health · Antioxidant Activity and Oxidative Stress
- Palabras clave
- eicosapentaenoic acid, docosahexaenoic acid, omega-3 supplementation, exercise-induced inflammation, oxidative stress, C-reactive protein, TNF-α, aerobic exercise, blood lactate, muscle soreness, creatine kinase, hydrogen peroxide, exercise-induced oxidative stress
- MeSH
- humans, inflammation, docosahexaenoic acids, eicosapentaenoic acid, tumor necrosis factor-alpha, c-reactive protein, body mass index, exercise, analysis of variance, cross-over studies, double-blind method, energy metabolism, oxidative stress, heart rate, physical fitness, dietary supplements, adult, male, young adult, biomarkers
5 autores
- Richard J. Bloomer🇺🇸 · autor de correspondenciaUniversity of Memphis
- Douglas E. Larson🇺🇸University of Memphis
- Kelsey H. Fisher‐Wellman🇺🇸University of Memphis
- Andrew J. Galpin🇺🇸University of Memphis
- Brian K. Schilling🇺🇸University of Memphis
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
The purpose of the present investigation was to determine the effects of EPA/DHA supplementation on resting and exercise-induced inflammation and oxidative stress in exercise-trained men. Fourteen men supplemented with 2224 mg EPA+2208 mg DHA and a placebo for 6 weeks in a random order, double blind cross-over design (with an 8 week washout) prior to performing a 60 minute treadmill climb using a weighted pack. Blood was collected pre and post exercise and analyzed for a variety of oxidative stress and inflammatory biomarkers. Blood lactate, muscle soreness, and creatine kinase activity were also measured.
Results
Treatment with EPA/DHA resulted in a significant increase in blood levels of both EPA (18 +/- 2 micromol x L(-1) vs. 143 +/- 23 micromol x L(-1); p 0.05). There was a mild increase in oxidative stress in response to exercise (XO and H2O2) (p < 0.05). No interaction effects were noted. However, a condition effect was noted for CRP and TNF-alpha, with lower values with the EPA/DHA condition.
Conclusion
EPA/DHA supplementation increases blood levels of these fatty acids and results in decreased resting levels of inflammatory biomarkers in exercise-trained men, but does not appear necessary for exercise-induced attenuation in either inflammation or oxidative stress. This may be due to the finding that trained men exhibit a minimal increase in both inflammation and oxidative stress in response to moderate duration (60 minute) aerobic exercise.
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