Panic disorder and social anxiety disorder subtypes in a caffeine challenge test
Nardi AE, Lopes FL, Freire RC, Veras AB, Nascimento I, Valença AM, de-Melo-Neto VL, Soares-Filho GL, King AL, Araújo DM, Mezzasalma MA, Rassi A, Zin WA
Psychiatry research · 39 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2009-08-27 · Psychiatry Res · vol. 169 · número 2 · págs. 149–153
- Editorial
- Elsevier BV
- Citado
- 75 citas · más que el 97% de estudios similares · 9.2× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 30 trabajos
- Acceso
- De pago
- Áreas de investigación
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes · Schizophrenia research and treatment · Coffee research and impacts
- Palabras clave
- panic disorder, social anxiety disorder, generalized social anxiety disorder, anxiety symptoms
- MeSH
- humans, caffeine, central nervous system stimulants, analysis of variance, double-blind method, social behavior, panic disorder, phobic disorders, psychiatric status rating scales, adolescent, adult, middle aged, young adult, surveys and questionnaires
13 autores
- Antônio Egídio Nardi🇧🇷 · autor de correspondenciaUniversidade Federal do Rio de Janeiro
- Fabiana L. Lopes🇧🇷Universidade Federal do Rio de Janeiro
- Rafael C. R. Freire🇧🇷Universidade Federal do Rio de Janeiro
- André Barciela Veras🇧🇷Universidade Federal do Rio de Janeiro
- Isabella Nascimento🇧🇷Universidade Federal do Rio de Janeiro
- Alexandre Martins Valença🇧🇷Universidade Federal do Rio de Janeiro
- Valfrido Leão de Melo Neto🇧🇷Universidade Federal do Rio de Janeiro
- Gastão L. Soares‐Filho🇧🇷Universidade Federal do Rio de Janeiro
- Anna Lucia Spear King🇧🇷Universidade Federal do Rio de Janeiro
- Daniele Marano Rocha Araújo🇧🇷Universidade Federal do Rio de Janeiro
- Marco A. Mezzasalma🇧🇷Universidade Federal do Rio de Janeiro
- Arabella Rassi🇧🇷Universidade Federal do Rio de Janeiro
- Walter Araujo Zin🇧🇷Universidade Federal do Rio de Janeiro; Instituto de Biofísica Carlos Chagas Filho
Resumen
El texto original del estudio, en el idioma en que se publicó.
Studies have demonstrated the vulnerability of anxiety disorder patients to challenge tests. Our aim was to observe if panic disorder (PD) patients and generalized social anxiety disorder (GSAD) and performance social anxiety disorder (PSAD) patients respond in a similar way to the induction of anxiety symptoms and panic attacks by an oral caffeine challenge test. We compared 28 PD patients, 25 GSAD patients, 19 PSAD, and 26 control subjects after a 480-mg caffeine test. The patients had not received psychotropic drugs for at least a 4-week period. In a randomized double-blind experiment performed in two occasions 7 days apart, 480 mg of caffeine and a caffeine-free solution were administered and anxiety scales were administered before and after each test. A panic attack was induced in 17 (60.7%) PD patients, 4 (16.0%) GSAD patients, and 10 (52.6%) PSAD patients, during the caffeine test. None of the control subjects had a panic attack after the caffeine intake. Neither patients nor any control subject had a panic attack after drinking the caffeine-free solution. Our data suggest that there is an association between PD and PSAD hyperreactivity to an oral caffeine challenge test. The PD and PSAD patients had a higher number of induced panic attacks, some specific anxiety symptoms, and a more severe anxiety response than GSAD patients and normal volunteers.
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