Treatment of vitamin D deficiency increases lower limb muscle strength in institutionalized older people independently of regular physical activity: a randomized double-blind controlled trial
Moreira-Pfrimer LD, Pedrosa MA, Teixeira L, Lazaretti-Castro M
Annals of nutrition & metabolism · 99 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2009-01-01 · Ann Nutr Metab · vol. 54 · número 4 · págs. 291–300
- Editorial
- Karger Publishers
- Citado
- 178 citas · más que el 98% de estudios similares · 8.6× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 49 trabajos
- Acceso
- De pago
- Áreas de investigación
- Vitamin D Research Studies · Nutrition and Health in Aging · Nutrition and Health Studies
- Palabras clave
- vitamin D deficiency, vitamin D3 supplementation, calcium supplementation, institutionalized elderly, lower limb muscle strength, hip flexors, knee extensors, 25-hydroxyvitamin D, parathyroid hormone, seasonal variation, hypercalcemia, physical inactivity
- MeSH
- lower extremity, humans, vitamin d deficiency, calcium, phosphorus, cholecalciferol, calcifediol, parathyroid hormone, double-blind method, seasons, dietary supplements, aged, aged, 80 and over, middle aged, homes for the aged, nursing homes, female, male, muscle strength, surveys and questionnaires
4 autores
- Linda Denise Fernandes Moreira🇧🇷Universidade Federal de São Paulo
- Márcia Alessandra Carneiro Pedrosa🇧🇷Universidade Federal de São Paulo
- Luzimar Raimundo Teixeira🇧🇷Universidade de São Paulo
- Marise Lazaretti‐Castro🇧🇷Universidade Federal de São Paulo
Resumen
El texto original del estudio, en el idioma en que se publicó.
Aims
To investigate the effects of a 6-month supplementation with calcium and cholecalciferol on biochemical parameters and muscle strength of institutionalized elderly.
Methods
This prospective, double-blind, placebo-controlled, randomized trial included Brazilian institutionalized people > or =60 years of age receiving a 6-month supplementation (December to May) of daily calcium plus monthly placebo (calcium/placebo group) or daily calcium plus oral cholecalciferol (150,000 IU once a month during the first 2 months, followed by 90,000 IU once a month for the last 4 months; calcium/vitamin D group). Fasting blood samples for 25(OH)D, PTH and calcium determination were collected (n = 56) and muscle tests were performed (n = 46) to measure the strength of hip flexors (SHF) and knee extensors (SKE) before (baseline) and after the 6-month intervention (6 months).
Results
Due to seasonal variations, serum 25(OH)D significantly enhanced in both groups after treatment, but the calcium/vitamin D group had significantly higher 25 (OH)D levels than the calcium/placebo group (84 vs. 33%, respectively; p < 0.0001). No cases of hypercalcemia were observed. While the calcium/placebo group showed no improvement in SHF and SKE at 6 months (p = 0.93 and p = 0.61, respectively), SHF was increased in the calcium/vitamin D group by 16.4% (p = 0.0001) and SKE by 24.6% (p = 0.0007).
Conclusions
The suggested cholecalciferol supplementation was safe and efficient in enhancing 25(OH)D levels and lower limb muscle strength in the elderly, in the absence of any regular physical exercise practice.
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