Three weeks of creatine monohydrate supplementation affects dihydrotestosterone to testosterone ratio in college-aged rugby players
van der Merwe J, Brooks NE, Myburgh KH
Clinical journal of sport medicine : official journal of the Canadian Academy of Sport Medicine · 13 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2009-09-01 · Clin J Sport Med · vol. 19 · número 5 · págs. 399–404
- Editorial
- Lippincott Williams & Wilkins
- Citado
- 29 citas · más que el 69% de estudios similares · 0.8× el promedio de su campo
- Referencias
- 44 trabajos
- Acceso
- De pago
- Áreas de investigación
- Muscle metabolism and nutrition · Hormonal and reproductive studies · Sports Performance and Training
- Palabras clave
- creatine monohydrate supplementation, dihydrotestosterone, testosterone, androgens, rugby players, creatine loading, ergogenic aids, body composition, long-term safety
- MeSH
- humans, creatine, dihydrotestosterone, testosterone, anthropometry, cross-over studies, double-blind method, football, dietary supplements, adolescent, male, young adult
3 autores
- Johann van der Merwe🇿🇦Stellenbosch University
- Naomi Elisabeth Brooks🇿🇦Stellenbosch University
- Kathryn Helen Myburgh🇿🇦Stellenbosch University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
This study investigated resting concentrations of selected androgens after 3 weeks of creatine supplementation in male rugby players. It was hypothesized that the ratio of dihydrotestosterone (DHT, a biologically more active androgen) to testosterone (T) would change with creatine supplementation.
Design
Double-blind placebo-controlled crossover study with a 6-week washout period.
Setting
Rugby Institute in South Africa.
Participants
College-aged rugby players (n = 20) volunteered for the study, which took place during the competitive season.
Interventions
Subjects loaded with creatine (25 g/day creatine with 25 g/day glucose) or placebo (50 g/day glucose) for 7 days followed by 14 days of maintenance (5 g/day creatine with 25 g/day glucose or 30 g/day glucose placebo).
Main outcome measures
Serum T and DHT were measured and ratio calculated at baseline and after 7 days and 21 days of creatine supplementation (or placebo). Body composition measurements were taken at each time point.
Results
After 7 days of creatine loading, or a further 14 days of creatine maintenance dose, serum T levels did not change. However, levels of DHT increased by 56% after 7 days of creatine loading and remained 40% above baseline after 14 days maintenance (P < 0.001). The ratio of DHT:T also increased by 36% after 7 days creatine supplementation and remained elevated by 22% after the maintenance dose (P < 0.01).
Conclusions
Creatine supplementation may, in part, act through an increased rate of conversion of T to DHT. Further investigation is warranted as a result of the high frequency of individuals using creatine supplementation and the long-term safety of alterations in circulating androgen composition. STATEMENT OF CLINICAL RELEVANCE: Although creatine is a widely used ergogenic aid, the mechanisms of action are incompletely understood, particularly in relation to dihydrotestosterone, and therefore the long-term clinical safety cannot be guaranteed.
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