Vitamin D supplementation reduces insulin resistance in South Asian women living in New Zealand who are insulin resistant and vitamin D deficient - a randomised, placebo-controlled trial
von Hurst PR, Stonehouse W, Coad J
The British journal of nutrition · 438 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Massey University
Según 1 financiador declarado.
Publicación
- Publicado
- 2009-09-28 · Br J Nutr · vol. 103 · número 4 · págs. 549–555
- Editorial
- Cambridge University Press
- Citado
- 624 citas · más que el 100% de estudios similares · 33.4× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 47 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Vitamin D Research Studies · Diabetes, Cardiovascular Risks, and Lipoproteins · Nutrition and Health Studies
- Palabras clave
- vitamin D supplementation, vitamin D deficiency, insulin resistance, insulin sensitivity, type 2 diabetes risk, South Asian women, 25-hydroxyvitamin D, HOMA-IR, fasting insulin, C-peptide, lipid profile, C-reactive protein
- MeSH
- humans, insulin resistance, vitamin d deficiency, cholecalciferol, insulin, vitamins, vitamin d, c-reactive protein, double-blind method, nutritional status, dietary supplements, adult, middle aged, asia, new zealand, female, insulin secretion, asian people
3 autores
- Pamela R. von Hurst🇳🇿 · autor de correspondenciaMassey University
- Welma Stonehouse🇳🇿Massey University
- Jane E. Coad🇳🇿Massey University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Low serum 25-hydroxyvitamin D (25(OH)D) has been shown to correlate with increased risk of type 2 diabetes. Small, observational studies suggest an action for vitamin D in improving insulin sensitivity and/or insulin secretion. The objective of the present study was to investigate the effect of improved vitamin D status on insulin resistance (IR), utilising randomised, controlled, double-blind intervention administering 100 microg (4000 IU) vitamin D(3) (n 42) or placebo (n 39) daily for 6 months to South Asian women, aged 23-68 years, living in Auckland, New Zealand. Subjects were insulin resistant - homeostasis model assessment 1 (HOMA1)>1.93 and had serum 25(OH)D concentration 25 microg (1000 IU)/d. The HOMA2 computer model was used to calculate outcomes. Median (25th, 75th percentiles) serum 25(OH)D(3) increased significantly from 21 (11, 40) to 75 (55, 84) nmol/l with supplementation. Significant improvements were seen in insulin sensitivity and IR (P = 0.003 and 0.02, respectively), and fasting insulin decreased (P = 0.02) with supplementation compared with placebo. There was no change in C-peptide with supplementation. IR was most improved when endpoint serum 25(OH)D reached > or = 80 nmol/l. Secondary outcome variables (lipid profile and high sensitivity C-reactive protein) were not affected by supplementation. In conclusion, improving vitamin D status in insulin resistant women resulted in improved IR and sensitivity, but no change in insulin secretion. Optimal vitamin D concentrations for reducing IR were shown to be 80-119 nmol/l, providing further evidence for an increase in the recommended adequate levels. Registered Trial No. ACTRN12607000642482.
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