Meta-analysis of vitamin D, calcium and the prevention of breast cancer
Chen P, Hu P, Xie D, Qin Y, Wang F, Wang H
Breast cancer research and treatment · 198 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Science Foundation
- Universidad u hospital
- Chinese Academy of Sciences
- Gobierno
- Ministry of Science and Technology of the People's Republic of China
- Gobierno
- Science and Technology Commission of Shanghai Municipality
Según 4 financiadores declarados.
Publicación
- Publicado
- 2009-10-22 · Breast Cancer Res Treat · vol. 121 · número 2 · págs. 469–477
- Editorial
- Springer Science+Business Media
- Citado
- 298 citas · más que el 91% de estudios similares · 2.4× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 58 trabajos
- Acceso
- De pago
- Áreas de investigación
- Vitamin D Research Studies · Nutritional Studies and Diet · Cancer Risks and Factors
- Palabras clave
- vitamin D, calcium intake, breast cancer prevention, 25-hydroxyvitamin D, 1,25-dihydroxyvitamin D, circulating vitamin D levels, chemoprevention, breast cancer risk
- MeSH
- humans, breast neoplasms, calcium, vitamins, vitamin d, diet, risk factors, dietary supplements, female
6 autores
- Peizhan Chen🇨🇳Chinese Academy of Sciences; Shanghai Institutes for Biological Sciences
- Pingting Hu🇨🇳Chinese Academy of Sciences; Shanghai Institutes for Biological Sciences
- Dong Xie🇨🇳Chinese Academy of Sciences; Shanghai Institutes for Biological Sciences
- Ying Qin🇨🇳Chinese Academy of Sciences; Shanghai Institutes for Biological Sciences
- Fudi Wang🇨🇳Chinese Academy of Sciences; Shanghai Institutes for Biological Sciences
- Hui Wang🇨🇳 · autor de correspondenciaChinese Academy of Sciences; Shanghai Institutes for Biological Sciences
Resumen
El texto original del estudio, en el idioma en que se publicó.
Vitamin D and calcium intake have been suggested to have protective effects against breast cancer; however, the data have been inconclusive. The present meta-analysis examined the overall effects of vitamin D intake, circulating 25(OH)D and 1alpha,25(OH)(2)D levels, and calcium intake on breast cancer risk. Data from 11 studies on vitamin D intake, 7 studies on circulating 25(OH)D levels, 3 studies of circulating 1alpha,25(OH)(2)D levels, and 15 studies on calcium intake and breast cancer risk were included in this analysis. From the meta-analysis, there was a significant inverse relationship between vitamin D intake and breast cancer risk, with an overall relative risk (RR) of high versus low vitamin D intake for breast cancer of 0.91 (95% CI = 0.85-0.97). The highest quantile of circulating 25(OH)D was found to be associated with a 45% (OR = 0.55, 95% CI = 0.38-0.80) decrease in breast cancer when compared with the lowest quantile. No significant association for the circulating 1alpha,25(OH)(2)D level and breast cancer was found (OR = 0.99, 95% CI = 0.68-1.44). For calcium, a 19% (RR = 0.81, 95% CI = 0.72-0.90) decrease in breast cancer risk was found for those with highest quantile of calcium intake compared to the lowest quantile. These results provide strong evidence that vitamin D and calcium have a chemopreventive effect against breast cancer.
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