Financiado en parte por Almond Board of California
Effect of almond-enriched high-monounsaturated fat diet on selected markers of inflammation: a randomised, controlled, crossover study
Rajaram S, Connell KM, Sabaté J
The British journal of nutrition · 89 citas
Etiquetas de revisión
Alimentación controladaFinanciado por la industriaSolo mecanismosDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Solo mecanismos
- Consumo medido con
- Comida provista por los investigadores
Quién lo pagó
- Financiación
- Financiado por la industria
- Grupo de la industria
- Almond Board of California
- Universidad u hospital
- University of California, Davis
Según 2 financiadores declarados.
Publicación
- Publicado
- 2009-10-29 · Br J Nutr · vol. 103 · número 6 · págs. 907–912
- Editorial
- Cambridge University Press
- Citado
- 134 citas · más que el 94% de estudios similares · 4.9× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 40 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Nuts composition and effects · Nutritional Studies and Diet · Fatty Acid Research and Health
- Palabras clave
- almond, monounsaturated fatty acids, inflammation, cardiovascular risk factors, E-selectin, C-reactive protein, interleukin-6, fibrinogen, tissue plasminogen activator, hemostasis, dietary intervention, dose-response relationship
- MeSH
- humans, prunus, nuts, inflammation, tissue plasminogen activator, dietary fats, unsaturated, fatty acids, monounsaturated, c-reactive protein, fibrinogen, e-selectin, interleukin-6, diet, cross-over studies, energy intake, hemostasis, adult, middle aged, female, male, biomarkers
3 autores
- Sujatha Rajaram🇺🇸 · autor de correspondenciaLoma Linda University
- Kristianne M. Connell🇺🇸Loma Linda University
- Joan Sabaté🇺🇸Loma Linda University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Frequent consumption of nuts lowers the risk of CHD. While lowering blood lipids is one of the mechanisms for cardioprotection, the present study sought to determine whether monounsaturated fat-rich almonds also influence other CHD risk factors such as inflammation and haemostasis. This was a randomised, controlled, crossover feeding study with twenty-five healthy adults (eleven men; fourteen women), age 22-53 years. Following a 2 week run-in phase (34 % energy from fat), subjects were assigned in random order to three diets for 4 weeks each: a heart-healthy control diet with no nuts ( < 30 % energy from fat), low-almond diet and high-almond diet (10 % or 20 % isoenergetic replacement of control diet with almonds, respectively). Serum E-selectin was significantly lower on the high-almond diet compared with the control diet. E-selectin decreased as the percentage of energy from almonds increased (P < 0.0001). C-reactive protein (CRP) was lower in both the almond diets compared with the control diet. A clear dose response was not observed for either E-selectin or CRP. There was no effect of diet on IL-6 or fibrinogen. Tissue plasminogen activator antigen was significantly lower on the control and high-almond diets compared with the low-almond diet, although the values were within normal range. In conclusion, consumption of almonds influenced a few but not all of the markers of inflammation and haemostasis. A clear dose response was not observed for any of the markers studied.
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