Effects of walnut consumption on endothelial function in type 2 diabetic subjects: a randomized controlled crossover trial
Ma Y, Njike VY, Millet J, Dutta S, Doughty K, Treu JA, Katz DL
Diabetes care · 153 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2009-10-30 · Diabetes Care · vol. 33 · número 2 · págs. 227–232
- Editorial
- American Diabetes Association
- Citado
- 201 citas · más que el 98% de estudios similares · 8.8× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 24 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY-NC-ND
- Áreas de investigación
- Nuts composition and effects · Nutritional Studies and Diet · Diabetes, Cardiovascular Risks, and Lipoproteins
- Palabras clave
- walnut consumption, type 2 diabetes, endothelial function, flow-mediated dilation, cardiovascular risk, LDL cholesterol, total cholesterol, serum lipids, insulin sensitivity, glycemic control
- MeSH
- brachial artery, endothelium, vascular, humans, juglans, hyperemia, diabetes mellitus, type 2, insulin, lipids, fasting, cross-over studies, single-blind method, vasodilation, adult, aged, middle aged, female, male, functional laterality, glycated hemoglobin
7 autores
- Yingying Ma🇺🇸Yale University
- Valentine Yanchou Njike🇺🇸Yale University
- John Millet🇺🇸Yale University
- Suparna Dutta🇺🇸Yale University
- Kimberly N. Doughty🇺🇸Yale University
- Judith A. Treu🇺🇸Yale University
- David L. Katz🇺🇸 · autor de correspondenciaYale University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
To determine the effects of daily walnut consumption on endothelial function, cardiovascular biomarkers, and anthropometric measures in type 2 diabetic individuals.
Research design and methods
This study was a randomized, controlled, single-blind, crossover trial. Twenty-four participants with type 2 diabetes (mean age 58 years; 14 women and 10 men) were randomly assigned to one of the two possible sequence permutations to receive an ad libitum diet enriched with 56 g (366 kcal) walnuts/day and an ad libitum diet without walnuts for 8 weeks. Subjects underwent endothelial function testing (measured as flow-mediated dilatation [FMD]) and assessment of cardiovascular biomarkers before and after each 8-week treatment phase. The primary outcome measure was the change in FMD after 8 weeks. Secondary outcome measures included changes in plasma lipids, A1C, fasting glucose, insulin sensitivity, and anthropometric measures.
Results
Endothelial function significantly improved after consumption of a walnut-enriched ad libitum diet compared with that after consumption of an ad libitum diet without walnuts (2.2 +/- 1.7 vs. 1.2 +/- 1.6%; P = 0.04). The walnut-enriched diet increased fasting serum glucose and lowered serum total cholesterol and LDL cholesterol from baseline (10.0 +/- 20.5 mg/dl, P = 0.04; -9.7 +/- 14.5 mg/dl, P < 0.01; and -7.7 +/- 10 mg/dl, P < 0.01, respectively), although these changes were not significant compared with those for an ad libitum diet without walnuts. There were no significant changes in anthropometric measures, plasma A1C, and insulin sensitivity.
Conclusions
A walnut-enriched ad libitum diet improves endothelium-dependent vasodilatation in type 2 diabetic individuals, suggesting a potential reduction in overall cardiac risk.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC-ND).
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