Dietary nitrate in Japanese traditional foods lowers diastolic blood pressure in healthy volunteers
Sobko T, Marcus C, Govoni M, Kamiya S
Nitric oxide : biology and chemistry · 118 citas
Etiquetas de revisión
Ancestral / evolutivoDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
- Enfoque
- Evidencia ancestral o evolutiva
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- National Center for Theoretical Sciences
- Gobierno
- Japan Society for the Promotion of Science
Según 2 financiadores declarados.
Publicación
- Publicado
- 2009-11-03 · Nitric Oxide · vol. 22 · número 2 · págs. 136–140
- Editorial
- Elsevier BV
- Citado
- 185 citas · más que el 96% de estudios similares · 6.1× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 46 trabajos
- Acceso
- De pago
- Áreas de investigación
- Nitric Oxide and Endothelin Effects · Sodium Intake and Health · Cardiovascular Health and Disease Prevention
- Palabras clave
- dietary nitrate, diastolic blood pressure, nitrite, blood pressure regulation, cardiovascular health, healthy longevity, plasma nitrate, salivary nitrate
- MeSH
- humans, vegetables, nitrates, diet, cross-over studies, blood pressure, reference values, adult, japan, female, male
4 autores
- Tanja Sobko🇯🇵🇸🇪 · autor de correspondenciaKyorin University; Karolinska Institutet
- Claude Marcus🇸🇪Karolinska Institutet
- Mirco Govoni🇸🇪Karolinska Institutet
- Shigeru Kamiya🇯🇵Kyorin University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Japanese longevity is the highest in the world. This is partly explained by low occurrence of cardiovascular diseases, which in turn is attributed to the Japanese traditional diet (JTD). Recent research demonstrates that nitric oxide (NO), a key regulator of vascular integrity, can be generated from nitrate (NO(3)(-)), abundantly found in vegetables. It can reduce blood pressure (BP) via its serial reduction to nitrite (NO(2)(-)) and to bioactive NO. Interestingly, JTD is extremely rich in nitrate and the daily consumption is higher than in any other known diet.
Objective and design
In a randomized, cross-over trial we examined the effect of a 10-day period of JTD on blood pressure in 25 healthy volunteers. Traditional Japanese vegetables were encouraged to be consumed and avoided during the control period. Daily nitrate intake was calculated.
Results
Nitrate naturally provided by the JTD was 18.8 mg/kg/bw/day, exceeding the Acceptable Daily Intake by five times (ADI, 3.7 mg/kg/bw). Plasma and salivary levels of nitrate and nitrite were higher at the end of the JTD period. Diastolic BP decreased on average 4.5 mmHg during JTD compared to the control diet (P=0.0066) while systolic BP was not affected. This effect was evident in normotensive subjects and similar to that seen in the recent studies.
Conclusions
An ordinary nitrate rich diet may positively affect blood pressure. Our findings further support the importance of the role of dietary nitrate on BP regulation suggesting one possible explanation of healthy aspects of traditional Japanese food.
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