Modulation of human serum glutathione S-transferase A1/2 concentration by cruciferous vegetables in a controlled feeding study is influenced by GSTM1 and GSTT1 genotypes
Navarro SL, Chang JL, Peterson S, Chen C, King IB, Schwarz Y, Li SS, Li L, Potter JD, Lampe JW
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 28 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Solo mecanismos
- Consumo medido con
- Comida provista por los investigadores
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Institutes of Health
- Gobierno
- National Cancer Institute
- Gobierno
- NCI NIH HHS
- Subvenciones
- National Cancer Institute (R01CA070913); National Cancer Institute (R25 CA094880)
Según 3 financiadores declarados.
Publicación
- Publicado
- 2009-11-01 · Cancer Epidemiol Biomarkers Prev · vol. 18 · número 11 · págs. 2974–2978
- Editorial
- American Association for Cancer Research
- Citado
- 42 citas · más que el 74% de estudios similares · 1.0× el promedio de su campo
- Referencias
- 28 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Glutathione Transferases and Polymorphisms · Genomics, phytochemicals, and oxidative stress · Pharmacogenetics and Drug Metabolism
- Palabras clave
- cruciferous vegetables, isothiocyanates, GSTM1 genotype, gene-diet interaction, dietary supplementation, sex differences, detoxification enzymes, controlled feeding study, chemoprevention, GSTM1 null genotype
- MeSH
- humans, vegetables, isoenzymes, glutathione transferase, prognosis, phytotherapy, cross-over studies, genotype, homozygote, adult, female, male, young adult, biomarkers, tumor
10 autores
- Sandi L. Navarro🇺🇸University of Minnesota; Fred Hutch Cancer Center
- Jyh-Lurn Chang🇺🇸University of Minnesota; Fred Hutch Cancer Center
- Sabrina P. Trudo🇺🇸University of Minnesota; Fred Hutch Cancer Center
- Chu Chen🇺🇸University of Minnesota; Fred Hutch Cancer Center
- Irena B. King🇺🇸University of Minnesota; Fred Hutch Cancer Center
- Yvonne Schwarz🇺🇸University of Minnesota; Fred Hutch Cancer Center
- Shuying S. Li🇺🇸University of Minnesota; Fred Hutch Cancer Center
- Lin Li🇺🇸University of Minnesota; Fred Hutch Cancer Center
- John D. Potter🇺🇸University of Minnesota; Fred Hutch Cancer Center
- Johanna W. Lampe🇺🇸 · autor de correspondenciaUniversity of Minnesota; Fred Hutch Cancer Center
Resumen
El texto original del estudio, en el idioma en que se publicó.
Glutathione S-transferases (GST) detoxify a wide range of carcinogens. Isothiocyanates (ITC), from cruciferous vegetables, are substrates for and inducers of GST. GST variants may alter ITC clearance such that response to crucifers varies by genotype. In a randomized cross-over trial, we tested the hypothesis that changes in serum GSTA1/2 concentration in response to cruciferous vegetable feeding depends on GSTM1/GSTT1 genotype. Thirty-three men and 34 women (age 20-40 years) ate four 14-day controlled diets--basal (vegetable-free), basal supplemented with two different doses of crucifers ("single dose" and "double dose"), and single-dose cruciferous-plus-apiaceous vegetables--fed per kilogram of body weight. Fasting bloods from days 0, 7, 11, and 14 of each diet period were analyzed for serum GSTA1/2 by ELISA. GSTA1/2 increased with single- and double-dose cruciferous compared with basal diet (10% and 13%, respectively; P = 0.02 and 0.004), but cruciferous-plus-apiaceous did not differ from basal (P = 0.59). Overall, GSTA1/2 was higher in GSTM1-null/GSTT1-null than GSTM1+/GSTT1+ individuals (4,198 +/- 338 and 3,372 +/- 183 pg/mL; P = 0.03). The formal interaction of genotype-by-diet was not statistically significant, but the GSTA1/2 increase during the single-dose cruciferous diet was among GSTM1-null/GSTT1-null individuals (by 28%; P = 0.008), largely explained by GSTM1-null/GSTT1-null men (by 41%; P = 0.01). GSTA1/2 increased during the double-dose cruciferous diet in both GSTM1-null/GSTT1-null men (by 35%; P = 0.04) and GSTM1+/GSTT1+ men (by 26%; P = 0.01) but not in women. In summary, cruciferous vegetable supplementation increased GSTA1/2, but the effect was most marked in GSTM1-null/GSTT1-null men.
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