Vitamin D insufficiency and health outcomes over 5 y in older women
Bolland MJ, Bacon CJ, Horne AM, Mason BH, Ames RW, Wang TK, Grey AB, Gamble GD, Reid IR
The American journal of clinical nutrition · 94 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2009-11-12 · Am J Clin Nutr · vol. 91 · número 1 · págs. 82–89
- Editorial
- Elsevier BV
- Citado
- 128 citas · más que el 98% de estudios similares · 9.5× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 41 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Vitamin D Research Studies · Nutrition and Health Studies · Bone health and osteoporosis research
- Palabras clave
- vitamin D insufficiency, 25-hydroxyvitamin D, older women, community-dwelling older adults, calcium supplementation, stroke, cardiovascular events, musculoskeletal outcomes, fracture, falls, bone mineral density, grip strength, comorbidities, seasonal variation, vitamin D supplementation
- MeSH
- humans, vitamin d deficiency, phosphates, calcium, cholecalciferol, hydroxycholecalciferols, lipids, hand strength, incidence, health status, postmenopause, blood pressure, bone density, dietary supplements, aged, aged, 80 and over, middle aged, female, fractures, bone
9 autores
- Mark J Bolland🇳🇿 · autor de correspondenciaUniversity of Auckland
- Catherine J. Bacon🇳🇿University of Auckland
- Anne M. Horne🇳🇿University of Auckland
- Barbara H Mason🇳🇿University of Auckland
- Ruth W Ames🇳🇿University of Auckland
- Tom KM Wang🇳🇿University of Auckland
- Andrew B. Grey🇳🇿University of Auckland
- Greg D. Gamble🇳🇿University of Auckland
- Ian R. Reid🇳🇿University of Auckland
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Vitamin D insufficiency was shown to be associated with adverse musculoskeletal and nonskeletal outcomes in numerous observational studies. However, some studies did not control for confounding factors such as age or seasonal variation of 25-hydroxyvitamin D [25(OH)D].
Objective
We sought to determine the effect of vitamin D status on health outcomes.
Design
Healthy community-dwelling women (n = 1471) with a mean age of 74 y were followed in a 5-y trial of calcium supplementation. 25(OH)D was measured at baseline in all women. Skeletal and nonskeletal outcomes were evaluated according to seasonally adjusted vitamin D status at baseline.
Results
Fifty percent of women had a seasonally adjusted 25(OH)D concentration or =50 nmol/L. Women with a seasonally adjusted 25(OH)D concentration <50 nmol/L had an increased incidence of stroke and cardiovascular events that did not persist after adjustment for between-group differences in age or comorbidities. Women with a seasonally adjusted 25(OH)D concentration <50 nmol/L were not at increased risk of adverse consequences for any musculoskeletal outcome, including fracture, falls, bone density, or grip strength or any nonskeletal outcomes, including death, myocardial infarction, cancer, heart failure, diabetes, or adverse changes in blood pressure, weight, body composition, cholesterol, or glucose.
Conclusions
Vitamin D insufficiency is more common in older, frailer women. Community-dwelling older women with a seasonally adjusted 25(OH)D concentration <50 nmol/L were not at risk of adverse outcomes over 5 y after control for comorbidities. Randomized placebo-controlled trials are needed to determine whether vitamin D supplementation in individuals with vitamin D insufficiency influences health outcomes. This trial was registered at www.anzctr.org.au as ACTRN 012605000242628.
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