Financiado en parte por California Walnut Commission
Walnut consumption increases satiation but has no effect on insulin resistance or the metabolic profile over a 4-day period
Brennan AM, Sweeney LL, Liu X, Mantzoros CS
Obesity (Silver Spring, Md.) · 66 citas
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Alimentación controladaFinanciado por la industriaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- Comida provista por los investigadores
Quién lo pagó
- Financiación
- Financiado por la industria
- Universidad u hospital
- Harvard Catalyst
- Grupo de la industria
- California Walnut Commission
- Gobierno
- National Institutes of Health
- Gobierno
- National Institute of Diabetes and Digestive and Kidney Diseases
- Gobierno
- National Center for Research Resources
- Gobierno
- NCRR NIH HHS
- Gobierno
- NIDDK NIH HHS
- Subvenciones
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK079929); National Institute of Diabetes and Digestive and Kidney Diseases (DK-081913); National Institute of Diabetes and Digestive and Kidney Diseases (R01DK058785); National Institute of Diabetes and Digestive and Kidney Diseases (K24DK081913); National Center for Research Resources (M01-RR-01032); National Institute of Diabetes and Digestive and Kidney Diseases (R56DK058785); National Center for Research Resources (M01RR001032); National Center for Research Resources (UL1RR025758); National Institute of Diabetes and Digestive and Kidney Diseases (DK 79929); National Institute of Diabetes and Digestive and Kidney Diseases (DK 58785); National Institutes of Health (DK58785)
Según 7 financiadores declarados.
Publicación
- Publicado
- 2009-11-12 · Obesity (Silver Spring) · vol. 18 · número 6 · págs. 1176–1182
- Editorial
- Wiley
- Citado
- 99 citas · más que el 89% de estudios similares · 2.7× el promedio de su campo
- Referencias
- 32 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Nuts composition and effects · Nutritional Studies and Diet · Nutrition, Health and Food Behavior
- Palabras clave
- walnut consumption, satiety, insulin resistance, metabolic syndrome, appetite, resting energy expenditure, satiety hormones, isocaloric diet, type 2 diabetes prevention
- MeSH
- humans, juglans, insulin resistance, placebos, cross-over studies, double-blind method, appetite, satiation, eating, time factors, middle aged, female, male, metabolome
4 autores
- Aoife Brennan🇺🇸Beth Israel Deaconess Medical Center; Harvard University
- Laura L. Sweeney🇺🇸Beth Israel Deaconess Medical Center; Harvard University
- Xiaowen Liu🇺🇸Beth Israel Deaconess Medical Center; Harvard University
- Christos Socrates Mantzoros🇺🇸 · autor de correspondenciaBeth Israel Deaconess Medical Center; Harvard University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Obesity and diabetes have been associated with increased consumption of highly processed foods, and reduced consumption of whole grains and nuts. It has been proposed, mainly on the basis of observational studies, that nuts may provide superior satiation, may lead to reduced calorie consumption, and may decrease the risk of type 2 diabetes; but evidence from randomized, interventional studies is lacking. A total of 20 men and women with the metabolic syndrome participated in a randomized, double-blind, crossover study of walnut consumption. Subjects had two 4-day admissions to the clinical research center where they were fed an isocaloric diet. In addition, they consumed shakes for breakfast containing either walnuts or placebo (shakes were standardized for calories, carbohydrate, and fat content). Appetite, insulin resistance, and metabolic parameters were measured. We found an increased level of satiety (overall P value = 0.0079) and sense of fullness (P = 0.05) in prelunch questionnaires following the walnut breakfast as compared to the placebo breakfast, with the walnut effect achieving significance on day 3 and 4 (P = 0.02 and P = 0.03). We did not find any change in resting energy expenditure, hormones known to mediate satiety, or insulin resistance when comparing the walnut vs. placebo diet. Walnut consumption over 4 days increased satiety by day 3. Long-term studies are needed to confirm the physiologic role of walnuts, the duration of time needed for these effects to occur, and to elucidate the underlying mechanisms.
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