Dietary nitrate reduces maximal oxygen consumption while maintaining work performance in maximal exercise
Larsen FJ, Weitzberg E, Lundberg JO, Ekblom B
Free radical biology & medicine · 224 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Vetenskapsrådet
- Gobierno
- Sixth Framework Programme
Según 2 financiadores declarados.
Publicación
- Publicado
- 2009-11-13 · Free Radic Biol Med · vol. 48 · número 2 · págs. 342–347
- Editorial
- Elsevier BV
- Citado
- 320 citas · más que el 100% de estudios similares · 54.0× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 48 trabajos
- Acceso
- De pago
- Áreas de investigación
- Cardiovascular and exercise physiology · Exercise and Physiological Responses · Nitric Oxide and Endothelin Effects
- Palabras clave
- dietary nitrate, VO2max, time to exhaustion, maximal exercise, nitric oxide, nitrite, employee performance, muscle energy metabolism
- MeSH
- humans, nitrates, aldosterone, renin, exercise test, pulmonary ventilation, exercise, double-blind method, oxygen consumption, renin-angiotensin system, heart rate, dietary supplements, adult, physical exertion
4 autores
- Filip Jon Larsen🇸🇪 · autor de correspondenciaKarolinska Institutet; Swedish School of Sport and Health Sciences
- Eddie Weitzberg🇸🇪Karolinska Institutet; Swedish School of Sport and Health Sciences
- Jon O. Lundberg🇸🇪Karolinska Institutet; Swedish School of Sport and Health Sciences
- Bjorn T. Ekblom🇸🇪Karolinska Institutet; Swedish School of Sport and Health Sciences
Resumen
El texto original del estudio, en el idioma en que se publicó.
The anion nitrate-abundant in our diet-has recently emerged as a major pool of nitric oxide (NO) synthase-independent NO production. Nitrate is reduced stepwise in vivo to nitrite and then NO and possibly other bioactive nitrogen oxides. This reductive pathway is enhanced during low oxygen tension and acidosis. A recent study shows a reduction in oxygen consumption during submaximal exercise attributable to dietary nitrate. We went on to study the effects of dietary nitrate on various physiological and biochemical parameters during maximal exercise. Nine healthy, nonsmoking volunteers (age 30+/-2.3 years, VO(2max) 3.72+/-0.33 L/min) participated in this study, which had a randomized, double-blind crossover design. Subjects received dietary supplementation with sodium nitrate (0.1 mmol/kg/day) or placebo (NaCl) for 2 days before the test. This dose corresponds to the amount found in 100-300 g of a nitrate-rich vegetable such as spinach or beetroot. The maximal exercise tests consisted of an incremental exercise to exhaustion with combined arm and leg cranking on two separate ergometers. Dietary nitrate reduced VO(2max) from 3.72+/-0.33 to 3.62+/-0.31 L/min, P<0.05. Despite the reduction in VO(2max) the time to exhaustion trended to an increase after nitrate supplementation (524+/-31 vs 563+/-30 s, P=0.13). There was a correlation between the change in time to exhaustion and the change in VO(2max) (R(2)=0.47, P=0.04). A moderate dietary dose of nitrate significantly reduces VO(2max) during maximal exercise using a large active muscle mass. This reduction occurred with a trend toward increased time to exhaustion implying that two separate mechanisms are involved: one that reduces VO(2max) and another that improves the energetic function of the working muscles.
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