Effect of short-term creatine supplementation on markers of skeletal muscle damage after strenuous contractile activity
Bassit RA, Pinheiro CH, Vitzel KF, Sproesser AJ, Silveira LR, Curi R
European journal of applied physiology · 50 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas, más trabajo en animales o laboratorio
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Fundação de Amparo à Pesquisa do Estado de São Paulo
Según 1 financiador declarado.
Publicación
- Publicado
- 2009-12-02 · Eur J Appl Physiol · vol. 108 · número 5 · págs. 945–955
- Editorial
- Springer Science+Business Media
- Citado
- 91 citas · más que el 82% de estudios similares · 1.8× el promedio de su campo
- Referencias
- 49 trabajos
- Acceso
- De pago
- Áreas de investigación
- Muscle metabolism and nutrition · Exercise and Physiological Responses · Muscle and Compartmental Disorders
- Palabras clave
- creatine supplementation, creatine monohydrate, skeletal muscle injury, exercise-induced muscle damage, creatine kinase, lactate dehydrogenase, aldolase, C-reactive protein, muscle fatigue, gastrocnemius, endurance exercise, triathletes
- MeSH
- muscle, skeletal, animals, humans, rats, rats, wistar, muscular diseases, creatine, placebos, drug administration schedule, drug evaluation, preclinical, electric stimulation, motor activity, muscle fatigue, muscle contraction, time factors, dietary supplements, adult, male, physical exertion, biomarkers
6 autores
- Reinaldo Abunasser Bassit🇧🇷 · autor de correspondenciaUniversidade de São Paulo
- Carlos Hermano da Justa Pinheiro🇧🇷Universidade de São Paulo
- Kaio Fernando Vitzel🇧🇷Universidade de São Paulo
- Antônio José Sproesser🇧🇷Universidade de São Paulo; Hospital Israelita Albert Einstein
- Leonardo R. Silveira🇧🇷Universidade de São Paulo
- Rui Curi🇧🇷Universidade de São Paulo
Resumen
El texto original del estudio, en el idioma en que se publicó.
The protective effect of short-term creatine supplementation (CrS) upon markers of strenuous contractile activity-induced damage in human and rat skeletal muscles was investigated. Eight Ironman triathletes were randomized into the placebo (Pl; n = 4) and creatine-supplemented (CrS; n = 4) groups. Five days prior to the Ironman competition, the CrS group received creatine monohydrate (20 g day(-1)) plus maltodextrin (50 g) divided in two equal doses. The Pl group received maltodextrin (50 g day(-1)) only. The effect of CrS (5 g day(-1)/kg body weight for 5 days) was also evaluated in a protocol of strenuous contractile activity induced by electrical stimulation in rats. Blood samples were collected before and 36 and 60 h after the competition and were used to determine plasma activities of creatine kinase (CK), lactate dehydrogenase (LDH), aldolase (ALD), glutamic oxaloacetic acid transaminase (GOT), glutamic pyruvic acid transaminase (GPT), and C-reactive protein (CRP) level. In rats, plasma activities of CK and LDH, muscle vascular permeability (MVP) using Evans blue dye, muscle force and fatigue were evaluated. Activities of CK, ALD, LDH, GOT, GTP, and levels of CRP were increased in the Pl group after the competition as compared to basal values. CrS decreased plasma activities of CK, LDH, and ALD, and prevented the rise of GOT and GPT plasma activities. In rats, CrS delayed the fatigue, preserved the force, and prevented the rise of LDH and CK plasma activities and MVP in the gastrocnemius muscle. CrS presented a protective effect on muscle injury induced by strenuous contractile activities.
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